Modelling the impact of larviciding on the population dynamics and biting rates of Simulium damnosum (s.l.): implications for vector control as a complementary strategy for onchocerciasis elimination in Africa.

Parasites & Vectors
Isobel RoutledgeMaría-Gloria Basáñez

Abstract

In 2012, the World Health Organization set goals for the elimination of onchocerciasis transmission by 2020 in selected African countries. Epidemiological data and mathematical modelling have indicated that elimination may not be achieved with annual ivermectin distribution in all endemic foci. Complementary and alternative treatment strategies (ATS), including vector control, will be necessary. Implementation of vector control will require that the ecology and population dynamics of Simulium damnosum (sensu lato) be carefully considered. We adapted our previous SIMuliid POPulation dynamics (SIMPOP) model to explore the impact of larvicidal insecticides on S. damnosum (s.l.) biting rates in different ecological contexts and to identify how frequently and for how long vector control should be continued to sustain substantive reductions in vector biting. SIMPOP was fitted to data from large-scale aerial larviciding trials in savannah sites (Ghana) and small-scale ground larviciding trials in forest areas (Cameroon). The model was validated against independent data from Burkina Faso/Côte d'Ivoire (savannah) and Bioko (forest). Scenario analysis explored the effects of ecological and programmatic factors such as pre-control daily b...Continue Reading

References

Jun 30, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R H BakerY Bissan
Oct 1, 1982·Annals of Tropical Medicine and Parasitology·R A ChekeM Kerner
Sep 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·E S AlleyE M Samba
Oct 1, 1993·Annals of Tropical Medicine and Parasitology·J M HougardD Quillévéré
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M G Basáñez, M Boussinesq
Jan 10, 2003·The American Journal of Tropical Medicine and Hygiene·María-Gloria BasáñezDavid Brandling-Bennett
Jan 1, 1986·Parasitology Today·D C Kurtak
Sep 28, 2006·PLoS Medicine·María-Gloria BasáñezMichel Boussinesq
Dec 5, 2006·Lancet·Uche Amazigo, Boakye Boatin
Sep 7, 2007·The New England Journal of Medicine·Peter J HotezLorenzo Savioli
Mar 18, 2009·Advances in Parasitology·María-Gloria BasáñezMaría-Eugenia Grillet
Apr 7, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·G A MatthewsM Birchmore
Nov 28, 2009·International Journal for Parasitology·Hans P Duerr, Martin Eichner
Feb 6, 2013·PLoS Neglected Tropical Diseases·Luc E CoffengUche V Amazigo
Jun 20, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hugo C TurnerMaría-Gloria Basáñez
Feb 18, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert A ChekeMichael D Wilson
Jun 2, 2015·International Journal of Environmental Research and Public Health·Céline Christiansen-JuchtPaul E Parham
Mar 24, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kwadwo K FrempongMaría-Gloria Basáñez
Aug 9, 2016·Parasites & Vectors·Poppy H L LambertonMaría-Gloria Basañez
Oct 21, 2016·Advances in Parasitology·M G BasáñezW A Stolk
Nov 9, 2017·The New England Journal of Medicine·Joseph KamgnoMichel Boussinesq
Jun 4, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suzanne VerverWilma A Stolk

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Software Mentioned

EPIONCHO
SIMPOP
SIMuliid POPulation
ONCHOSIM
Bioko
abc R

Related Concepts

Related Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.