Modelling the impact of multiple sclerosis on life expectancy, quality-adjusted life years and total lifetime costs: Evidence from Australia.

Multiple Sclerosis : Clinical and Laboratory Research
Andrew J PalmerHasnat Ahmad

Abstract

To quantify life expectancy (LE), quality-adjusted life years (QALYs) and total lifetime societal costs for a hypothetical cohort of Australians with multiple sclerosis (MS). A 4-state Markov model simulated progression from no/mild to moderate and severe disability and death for a cohort of 35-year-old women over a lifetime horizon. Death risks were calculated from Australian life tables, adjusted by disability severity. State-dependent relapse probabilities and associated disutilities were considered. Probabilities of MS progression and relapse were estimated from AusLong and TasMSL MS epidemiological databases. Annual societal (direct and indirect) costs (2017 Australian dollars) and health-state utilities for each state were derived from the Australian MS Longitudinal Study. Costs were discounted at 5% annually. Mean (95% confidence interval (CI)) LE from age 35 years was 42.7 (41.6-43.8) years. This was 7.5 years less than the general Australian population. Undiscounted QALYs were 28.2 (26.3-30.0), a loss of 13.1 QALYs versus the Australian population. Discounted lifetime costs were $942,754 ($347,856-$2,820,219). We have developed a health economics model of the progression of MS, calculating the impact of MS on LE, QALYs...Continue Reading

References

Mar 8, 1998·PharmacoEconomics·A Briggs, M Sculpher
Apr 25, 2000·Multiple Sclerosis : Clinical and Laboratory Research·D T GrimaL Lafortune
Mar 5, 2002·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Mark J C Nuijten, John Hutton
May 13, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·G KobeltB Jönsson
Nov 11, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Michael DrummondJohan Severens
Sep 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Rosalie VineyJulie Ratcliffe
Jan 1, 2009·ClinicoEconomics and Outcomes Research : CEOR·Ceri J Phillips, Ioan Humphreys
Jun 12, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·John Slof, Adrien Gras
Sep 20, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Andrew H BriggsUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Uwe SiebertUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Mar 27, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Bruce V TaylorDavid Abernethy
May 9, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Andrew J PalmerRex D Simmons
Jul 10, 2013·Neurology·Antonio ScalfariGeorge C Ebers
Jan 16, 2014·Autoimmunity Reviews·Ron Milo, Ariel Miller
Apr 17, 2015·Multiple Sclerosis and Related Disorders·Jonathan D CampbellKavita Nair
Apr 22, 2015·Multiple Sclerosis and Related Disorders·K O'ConnellN Tubridy
Jan 29, 2016·Applied Health Economics and Health Policy·Drew CarterHossein Haji Ali Afzali
Oct 5, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Hasnat AhmadAndrew J Palmer
Oct 24, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Hasnat AhmadAndrew J Palmer

❮ Previous
Next ❯

Citations

May 16, 2019·Expert Opinion on Pharmacotherapy·Emanuele D'AmicoFrancesco Patti
Jul 19, 2021·Multiple Sclerosis and Related Disorders·Hasnat AhmadAndrew J Palmer

❮ Previous
Next ❯

Software Mentioned

msm R
ISPOR
TreeAge Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Multiple Sclerosis : Clinical and Laboratory Research
Andrew J PalmerRex D Simmons
Scandinavian Journal of Public Health
Henrik Brønnum-HansenJan Sørensen
The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine
Li Y WangRichard Lowry
© 2022 Meta ULC. All rights reserved