Modelling the inactivation of viruses from the Coronaviridae family in response to temperature and relative humidity in suspensions or surfaces

Applied and Environmental Microbiology
Laurent GuillierCovid-19 Emergency Collective Expert Appraisal Group

Abstract

Temperature and relative humidity are major factors determining virus inactivation in the environment. This article reviews inactivation data of coronaviruses on surfaces and in liquids from published studies and develops secondary models to predict coronaviruses inactivation as a function of temperature and relative humidity. A total of 102 D-values (time to obtain a log10 reduction of virus infectivity), including values for SARS-CoV-2, were collected from 26 published studies. The values obtained from the different coronaviruses and studies were found to be generally consistent. Five different models were fitted to the global dataset of D-values. The most appropriate model considered temperature and relative humidity. A spreadsheet predicting the inactivation of coronaviruses and the associated uncertainty is presented and can be used to predict virus inactivation for untested temperatures, time points or any coronavirus strains belonging to Alphacoronavirus and Betacoronavirus genera.Importance: The prediction of the persistence of SARS-CoV-2 on fomites is essential to investigate the importance of contact transmission. This study collects available information on inactivation kinetics of coronaviruses in both solid and liq...Continue Reading

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Citations

Oct 9, 2020·Virology Journal·Shane RiddellTrevor W Drew
Jan 4, 2021·Environmental Science and Pollution Research International·Angeles BlancoCarlos Negro
Feb 3, 2021·Critical Reviews in Food Science and Nutrition·Fabio MasottiIvano De Noni
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Mar 27, 2021·Journal of Food Protection·Megan Rose-MartelEnrico Buenaventura
Aug 6, 2021·Environmental Research·Enric Cuevas-FerrandoGloria Sánchez

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Methods Mentioned

BETA
reverse transcription-PCR

Software Mentioned

Excel
digitize R
R
nlsMicrobio R package

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