Modelling the long-term persistence of neutralizing antibody in adults after one dose of live attenuated Japanese encephalitis chimeric virus vaccine

Vaccine
Kamal DesaiF Bailleux

Abstract

In a study conducted in a non-endemic area, a live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) was found to provide 97% seroprotection at 6 months in JE-naive adults after 1 dose, and 87% of those protected at 6 months were still protected at 5 years. Because long-term seroprotection data are essential for decision-making on the need and timing of boosters, we applied statistical models to this dataset to predict individuals' neutralizing antibody titres and seroprotection up to 25 years post-vaccination. Three types of statistical model (linear, piecewise linear and exponential-type) with fixed and random effects were constructed to model antibody decline from the observed peak in antibody levels measured 28 days after vaccination. Individual seroprotection was based on the accepted threshold of 1:10 dilution units (antibody titre ≥10). The piecewise linear mixed model provided best fit amongst all tested models and identified 2 periods of antibody decline: an initial period of rapid decline followed by a period of much slower decline (50 times) starting on average 3.2 months (5th to 95th percentile range: 1.4-7.3) after vaccination. Predicted median antibody titres at 10 years were 38 (<10-174) and the cor...Continue Reading

References

Mar 17, 2001·Statistics in Medicine·D RenardP Van Damme
Oct 28, 2008·Biological Chemistry·Erich Tauber, Shailesh Dewasthaly
Mar 26, 2011·Expert Review of Vaccines·Scott B Halstead, Stephen J Thomas

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Citations

Aug 20, 2014·Infectious Diseases and Therapy·Ruth Chin, Joseph Torresi
Apr 7, 2015·Journal of the Chinese Medical Association : JCMA·Hui-Lan ChenRen-Bin Tang
Jul 31, 2013·Biologicals : Journal of the International Association of Biological Standardization·Dennis W TrentUNKNOWN WHO Working Group on the Quality, Safety and Efficacy of Japanese Encephalitis Vaccines Live Attenuated for Human Use
Apr 29, 2015·Journal of Wildlife Diseases·Eileen M McKeeGabriel L Hamer
Mar 13, 2015·The Pediatric Infectious Disease Journal·Eduardo L LópezJudith Armoni
Nov 4, 2017·Science·Leah C KatzelnickEva Harris
Mar 17, 2017·Human Vaccines & Immunotherapeutics·Nagendra R Hegde, Milind M Gore
Aug 24, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Hee-Jung LeeYoung Bong Kim

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