Modelling the metastatic cascade by in vitro microfluidic platforms

Progress in Histochemistry and Cytochemistry
Timur R SamatovAlexander G Tonevitsky

Abstract

The metastatic cascade comprises the following steps in sequential manner: the future metastatic cell has to leave the primary tumor mass, degrade the surrounding extracellular matrix, extravasate and circulate within in the bloodstream. Thereafter it has to attach to the endothelium of a target organ, intravasate into the connective tissue and has to proliferate to form a clinically detectable metastasis. We overview the in vitro microfluidic platforms modelling the metastatic cascade and the evolution towards systems capable of recapitulating all the steps by a single comprehensive model.

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Citations

May 12, 2016·Bulletin of Experimental Biology and Medicine·A V AleksandrovaD A Sakharov
Jun 5, 2016·Bulletin of Experimental Biology and Medicine·T N GerasimenkoS A Tonevitskaya
Jun 7, 2016·Bulletin of Experimental Biology and Medicine·A V AlexandrovaD A Sakharov
Aug 9, 2016·Bulletin of Experimental Biology and Medicine·O V SemenovaD A Sakharov
Sep 19, 2016·Seminars in Cancer Biology·Timur R SamatovUdo Schumacher
Sep 8, 2020·Doklady. Biochemistry and Biophysics·M Yu ShkurnikovE N Knyazev
Sep 8, 2020·Doklady. Biochemistry and Biophysics·S A NersisyanE N Knyazev
Sep 14, 2018·Frontiers in Cell and Developmental Biology·Zhe WangMargot Zöller
May 26, 2018·Bulletin of Experimental Biology and Medicine·O A BurmistrovaM Yu Shkurnikov
Feb 11, 2020·Frontiers in Bioengineering and Biotechnology·Tatiana GerasimenkoAlexander Tonevitsky
Mar 28, 2018·Bulletin of Experimental Biology and Medicine·S V NikulinM Yu Shkurnikov
Aug 31, 2017·Bulletin of Experimental Biology and Medicine·D V MaltsevaM Yu Shkurnikov
Jun 18, 2021·Frontiers in Genetics·Stepan NersisyanAlexander Tonevitsky
Jun 22, 2021·Frontiers in Genetics·Sergey NikulinAlexander Tonevitsky
Jul 15, 2021·APL Bioengineering·I RisueñoD Velasco
Aug 25, 2021·Doklady. Biochemistry and Biophysics·E N KnyazevA G Tonevitsky

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