Modelling the relationship between antibody-dependent enhancement and immunological distance with application to dengue

Journal of Theoretical Biology
Ben Adams, Michael Boots

Abstract

When antibodies raised in response to a particular pathogen bind with immunologically similar pathogens it may facilitate infection through a phenomenon known as antibody-dependent enhancement (ADE). This process occurs between the four serotypes of dengue virus and, furthermore, secondary infection is a major risk factor in dengue hemorrhagic fever (DHF). Theory has suggested that ADE may be responsible for the large immunological distance between dengue serotypes. We investigate this hypothesis using an epidemic model for dengue in which immunological distance and the strength of immune cross-reaction are expressed separately. Cross-enhancement is considered in three alternative forms acting on susceptibility, transmission and mortality. Previous models have shown that transmission and mortality enhancement can lead to periodicity or chaos. We confirm this result for reasonable levels of susceptibility and transmission enhancement but not for mortality enhancement. We also show that when the two strains have identical basic reproductive numbers no form of enhancement leads to competitive exclusion. When the two strains have different basic reproductive numbers susceptibility or transmission enhancement allow strains with grea...Continue Reading

References

Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·N FergusonS Gupta
Apr 20, 1999·Virology·A L Rothman, F A Ennis
Jun 12, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N M FergusonR M Anderson
Dec 23, 1999·The Journal of Infectious Diseases·D W VaughnA Nisalak
May 29, 2000·Emerging Infectious Diseases·A P Trravassos da RosaJ F Travassos Da Rosa
Sep 1, 2000·Microbes and Infection·W J McBride, H Bielefeldt-Ohmann
Mar 14, 2003·Journal of Virology·Raymond Cologna, Rebeca Rico-Hesse
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Edward C Holmes, S Susanna Twiddy
Aug 2, 2003·Emerging Infectious Diseases·Pallavi GargO Colin Stine
Nov 20, 2003·Reviews in Medical Virology·Ayato Takada, Yoshihiro Kawaoka
Jan 17, 2004·Science·Bryan T GrenfellEdward C Holmes
Mar 12, 2004·Molecular Ecology·Edward C Holmes
Apr 2, 2004·The Journal of Clinical Investigation·Alan L Rothman
Oct 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Derek A T CummingsDonald S Burke

❮ Previous
Next ❯

Citations

Mar 29, 2013·Bulletin of Mathematical Biology·Harriet Hughes, N F Britton
May 15, 2013·Journal of Theoretical Biology·Luis Mier-y-Teran-RomeroDerek A T Cummings
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yoshiro Nagao, Katia Koelle
Jul 31, 2007·Bioinformatics·Milind Misra, Catherine H Schein
Oct 14, 2011·Viruses·Rubing Chen, Nikos Vasilakis
Nov 26, 2015·Mathematical Biosciences·Ahmed AbdelrazecHuaiping Zhu
Feb 27, 2014·Journal of Theoretical Biology·Hannah Woodall, Ben Adams
Sep 21, 2016·International Journal of Environmental Research and Public Health·Tiago França Melo de LimaClodoveu Augusto Davis Junior
Nov 4, 2016·The American Journal of Tropical Medicine and Hygiene·Eunha Shim
Jul 30, 2011·Current Opinion in Infectious Diseases·Stephen J Thomas, Timothy P Endy
May 14, 2017·The American Journal of Tropical Medicine and Hygiene·Eunha Shim
Apr 11, 2018·Evolutionary Applications·José LourençoMario Recker
Nov 19, 2021·Science·Leah C KatzelnickDerek A T Cummings

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Enhancement

Antibody-dependent enhancement of viral infection is the entry of virus into host cells mediated by antiviral antibodies interacting with Fc or complement receptors. This has been most extensively observed with the dengue virus. Find the latest research on antibody-dependent enhancement here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Derek A T CummingsDonald S Burke
Proceedings of the National Academy of Sciences of the United States of America
Helen J Wearing, Pejman Rohani
© 2022 Meta ULC. All rights reserved