Modelling the spatial-temporal progression of the 2009 A/H1N1 influenza pandemic in Chile

Mathematical Biosciences and Engineering : MBE
Raimund BürgerLuis M Villada

Abstract

A spatial-temporal transmission model of 2009 A/H1N1 pandemic influenza across Chile, a country that spans a large latitudinal range, is developed to characterize the spatial variation in peak timing of that pandemic as a function of local transmission rates, spatial connectivity assumptions for Chilean regions, and the putative location of introduction of the novel virus into the country. Specifically, a metapopulation SEIR (susceptible-exposed-infected-removed) compartmental model that tracks the transmission dynamics of influenza in 15 Chilean regions is calibrated. The model incorporates population mobility among neighboring regions and indirect mobility to and from other regions via the metropolitan central region ('hub region'). The stability of the disease-free equilibrium of this model is analyzed and compared with the corresponding stability in each region, concluding that stability may occur even with some regions having basic reproduction numbers above 1. The transmission model is used along with epidemiological data to explore potential factors that could have driven the spatial-temporal progression of the pandemic. Simulations and sensitivity analyses indicate that this relatively simple model is sufficient to char...Continue Reading

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Citations

Jul 28, 2016·Physics of Life Reviews·Gerardo ChowellCécile Viboud
Nov 1, 2016·Journal of Mathematical Biology·Seong-Hun Paeng, Jonggul Lee
Nov 23, 2017·Mathematical Biosciences and Engineering : MBE·Vasiliy N Leonenko, Sergey V Ivanov
Nov 23, 2017·Mathematical Biosciences and Engineering : MBE·Raimund BürgerLuis M Villada

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