PMID: 9631299Jun 19, 1998Paper

Models and simulations of ion channels and related membrane proteins

Current Opinion in Structural Biology
Mark S P Sansom

Abstract

The past year has seen major advances in our understanding of ion channels, resulting from molecular dynamics simulations and modelling studies. Simulations of gramicidin have revealed that proton conduction along a water wire is limited by the dynamics of water reorientation. Plausible models are now available for a number of other channels, including alamethicin, the influenza A virus M2 protein, and the pore domains of the nicotinic acetylcholine receptor and Kv channels. Molecular dynamics simulations and continuum calculations have revealed some of the subtleties of the interactions between transmembrane helices and their lipid bilayer environment.

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Citations

Feb 27, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M S SansomR Bull
Mar 13, 1999·Biophysical Chemistry·P C Biggin, M S Sansom
Apr 8, 2000·Current Opinion in Structural Biology·L R Forrest, M S Sansom
Jan 5, 2002·Journal of Molecular Graphics & Modelling·C T ChomaH J Berendsen
Oct 26, 2002·Journal of Molecular Graphics & Modelling·Jeffrey Sutherland, Gustavo A Arteca
Jun 20, 2006·Biophysical Journal·David Y HaubertinStéphane Orlowski
Oct 8, 2013·Biophysical Journal·Thuy Hien T NguyenPreston B Moore
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Jul 15, 2011·Brazilian Journal of Biology = Revista Brasleira De Biologia·A R Nascimento, A M Penteado-Dias
Dec 23, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Usha DeviSimon J Webb

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