Models for estimating the number of unpublished studies

Statistics in Medicine
L J Gleser, I Olkin

Abstract

The possible existence of unreported studies can cast doubt on the conclusions of a meta-analytic summary of the literature, particularly if there is reason to believe that there is a publication bias against non-significant results. The present article proposes two general models that describe how the preponderance of published studies could report significant p-values even when testing a null hypothesis that is, in fact, true. Each such model allows one to estimate the number, N, of unpublished studies using the p-values reported in the published studies; the meta-analyst can then evaluate the plausibility of this estimated value of N, or related confidence bounds. Use of models of the kind suggested here allows meta-analysts to assess the problem of unpublished studies from various perspectives and thus can lead to greater understanding of, and confidence in, meta-analytic conclusions.

Citations

Oct 22, 2010·BMJ : British Medical Journal·Jeffrey L JacksonPatrick G O'Malley
Feb 19, 2011·American Journal of Public Health·Vicki S ConnDavid R Mehr
Oct 13, 2009·The Journal of Antimicrobial Chemotherapy·José A Pérez-MolinaRogelio López-Velez
Oct 26, 2005·Neurosurgical Focus·Fred G Barker, Bob S Carter
Jun 12, 2002·Biological Reviews of the Cambridge Philosophical Society·Michael D Jennions, Anders P Møller
May 8, 2008·Chest·Gustavo J RodrigoRoberto Rodríguez-Roisin
Dec 29, 2000·Mayo Clinic Proceedings·V M MontoriG H Guyatt
Mar 3, 2007·The Lancet Oncology·Val GebskiUNKNOWN Australasian Gastro-Intestinal Trials Group
Jun 24, 2003·Statistics in Medicine·Norma TerrinIngram Olkin
Jun 22, 2016·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Foruhar MoayeriDavid Dunt
Dec 29, 1998·Annals of Emergency Medicine·W R Mower
Jun 21, 2011·The Lancet Oncology·Katrin M SjoquistUNKNOWN Australasian Gastro-Intestinal Trials Group
Apr 10, 2012·Schizophrenia Research·Helen NiemeyerReinhard Pietrowsky
Aug 13, 2002·BMC Medical Research Methodology·Nancy G Berman, Robert A Parker
Aug 10, 2016·Journal of Clinical Epidemiology·Katharina Felicitas MuellerDirk Bassler
Mar 30, 2001·ANZ Journal of Surgery·G K Kiroff
Sep 4, 1999·Statistics in Medicine·I Olkin
May 24, 2014·The Journal of Primary Prevention·Vicki S ConnJo-Ana D Chase
Dec 28, 2016·Statistical Methods in Medical Research·Qiaohao Zhu, K C Carriere
Jan 15, 2002·Genetic Epidemiology·D V ZaykinB S Weir
Jan 29, 2003·Nursing Research·Karen L Soeken, Acharaporn Sripusanapan
Jan 26, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rebecca AsherVal Gebski
Jul 1, 1998·Clinical Obstetrics and Gynecology·S B ThackerH B Peterson
Jul 21, 2006·The Cochrane Database of Systematic Reviews·S BhogalF M Ducharme
Apr 16, 2010·The Cochrane Database of Systematic Reviews·Francine M DucharmeToby J Lasserson
Sep 8, 2020·Research Synthesis Methods·Arielle Marks-Anglin, Yong Chen
Jul 9, 1998·Statistical Methods in Medical Research·A K Hackshaw
Feb 24, 2001·Statistical Methods in Medical Research·A J SuttonK R Abrams
Jan 1, 2014·International Scholarly Research Notices·Konstantinos C FragkosChristos C Frangos

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