Models for Nociception Stimulation and Memory Effects in Awake and Aware Healthy Individuals

IEEE Transactions on Bio-medical Engineering
Dana Copot, Clara Ionescu

Abstract

This paper introduces a primer in the health care practice, namely a mathematical model and methodology for detecting and analysing nociceptor stimulation followed by related tissue memory effects. Noninvasive nociceptor stimulus protocol and prototype device for measuring bioimpedance is provided. Various time instants, sensor location, and stimulus train have been analysed. The method and model indicate that nociceptor stimulation perceived as pain in awake healthy volunteers is noninvasively detected. The existence of a memory effect is proven from data. Sensor location had minimal effect on detection level, while day-to-day variability was observed without being significant. Following the experimental study, the model enables a comprehensive management of chronic pain patients, and possibly other analgesia, or pain related regulatory loops. A device and methodology for noninvasive for detecting nociception stimulation have been developed. The proposed method and models have been validated on healthy volunteers.

Citations

May 12, 2020·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·C M IonescuR Caponetto
Dec 2, 2020·Sensors·Mihaela GhitaClara M Ionescu

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