Models for the study of Clostridium difficile infection.

Gut Microbes
Emma L BestM H Wilcox

Abstract

Models of Clostridium difficile infection (C. difficile) have been used extensively for Clostridium difficile (C. difficile) research. The hamster model of C. difficile infection has been most extensively employed for the study of C. difficile and this has been used in many different areas of research, including the induction of C. difficile, the testing of new treatments, population dynamics and characterization of virulence. Investigations using in vitro models for C. difficile introduced the concept of colonization resistance, evaluated the role of antibiotics in C. difficile development, explored population dynamics and have been useful in the evaluation of C. difficile treatments. Experiments using models have major advantages over clinical studies and have been indispensible in furthering C. difficile research. It is important for future study programs to carefully consider the approach to use and therefore be better placed to inform the design and interpretation of clinical studies.

References

Oct 1, 1979·Applied and Environmental Microbiology·A B OnderdonkJ G Bartlett
May 20, 1978·Lancet·H E LarsonS P Borriello
Apr 15, 1978·Lancet·W L GeorgeS M Finegold
Aug 1, 1979·Antimicrobial Agents and Chemotherapy·R ToshniwalJ Silva
Apr 1, 1978·The Journal of Infectious Diseases·R H LuskG D Abrams
Jan 1, 1979·The American Journal of Clinical Nutrition·R FeketyJ R Ebright
Nov 1, 1977·The Journal of Infectious Diseases·J G BartlettD L Kasper
Aug 1, 1992·The Journal of Antimicrobial Chemotherapy·C L GolledgeT V Riley
Jun 1, 1992·Antimicrobial Agents and Chemotherapy·M C BarcP Bourlioux
Jun 1, 1991·Antimicrobial Agents and Chemotherapy·R N SwansonJ J Clement
Dec 1, 1990·Journal of Medical Microbiology·S P Borriello
Jan 1, 1990·Reviews of Infectious Diseases·T W ChangS L Gorbach
Jul 1, 1990·Antimicrobial Agents and Chemotherapy·H E Larson, S P Borriello
Jul 1, 1987·Antimicrobial Agents and Chemotherapy·M Y DongS L Gorbach
Mar 1, 1986·The Journal of Infectious Diseases·K H WilsonD Lyerly
Dec 1, 1986·The Journal of Antimicrobial Chemotherapy·D S WeinbergR B Sykes
Aug 1, 1987·Gastroenterology·G TriadafilopoulosJ T LaMont
Jun 1, 1986·Journal of Medical Microbiology·S P Borriello, F E Barclay
Jan 1, 1987·Infection and Immunity·E L MullerW L George
Feb 1, 1985·Infection and Immunity·D M LyerlyT D Wilkins
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·R D Toothaker, G W Elmer
Nov 1, 1983·Infection and Immunity·R D Rolfe, J P Iaconis
Mar 1, 1984·Reviews of Infectious Diseases·J SilvaJ Lukens
Jan 1, 1984·Scandinavian Journal of Infectious Diseases·A SchwanB Aronsson
Mar 1, 1981·The Journal of Infectious Diseases·R D RolfeS M Finegold
Apr 1, 1983·The Journal of Infectious Diseases·K H Wilson, J N Sheagren
Jun 1, 1981·Antimicrobial Agents and Chemotherapy·J R EbrightK H Wilson
Jan 1, 1982·Microbiology and Immunology·S NakamuraS Nishida
Jan 1, 1981·The Journal of Infectious Diseases·R ToshniwalK H Kim
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·A B Onderdonk, J G Bartlett

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Citations

Jan 29, 2013·The Journal of Antimicrobial Chemotherapy·Simon D BainesMark H Wilcox
Sep 12, 2013·PloS One·Amber HowertonErnesto Abel-Santos
May 7, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mark H Wilcox
Sep 25, 2014·Annual Review of Genetics·Sophie Yurist-DoutschB Brett Finlay
Oct 30, 2012·The Journal of Infection·A M JonesM H Wilcox
Mar 12, 2015·Journal of Medicinal Chemistry·Angie M JarradMatthew A Cooper
Jan 30, 2014·Environmental Microbiology·Sandra Macfarlane
May 10, 2016·Nature Reviews. Disease Primers·Wiep Klaas SmitsEd J Kuijper
Aug 21, 2015·Microbiome·James CollinsRobert A Britton
Jan 15, 2015·Infectious Disease Clinics of North America·Caroline H Chilton, Jane Freeman
Jan 13, 2015·Infectious Disease Clinics of North America·Tanya M Monaghan
Jan 1, 2014·FEMS Microbiology Letters·Melanie L HuttonDena Lyras
Jun 11, 2016·International Journal of Antimicrobial Agents·Richard J VickersMark H Wilcox
Feb 27, 2016·Molecular Microbiology·Adrianne N EdwardsShonna M McBride
Oct 22, 2015·Annual Review of Microbiology·Casey M Theriot, Vincent B Young
Mar 23, 2017·Environmental Microbiology·Zulema UdaondoJuan-Luis Ramos
Feb 28, 2018·Antimicrobial Agents and Chemotherapy·Ilana L StrokeDavid W Hilbert
Jul 30, 2014·Infection and Immunity·Adrianne N EdwardsShonna M McBride
Dec 24, 2014·Infection and Immunity·Mark J KoenigsknechtVincent B Young
Aug 1, 2018·Antimicrobial Agents and Chemotherapy·Charles BurdetJean de Gunzburg
Dec 9, 2015·Antimicrobial Agents and Chemotherapy·Janet Y NaleMartha R J Clokie
Jun 4, 2014·Antimicrobial Agents and Chemotherapy·Hon Wai KoonCharalabos Pothoulakis
Jun 19, 2015·Clinical Microbiology Reviews·Daniel R KnightThomas V Riley
Apr 17, 2019·The Journal of Antimicrobial Chemotherapy·C M RooneyC H Chilton
Jul 19, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·L CussóE Bouza
Aug 27, 2019·Frontiers in Cellular and Infection Microbiology·Stephanie D JurburgJohanna M J Rebel
Dec 28, 2018·The Journal of Antimicrobial Chemotherapy·J J VernonJ Freeman

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