PMID: 7085303May 1, 1982Paper

Models of Am metabolism in beagles and humans

Health Physics
J A Mewhinney, W C Griffith

Abstract

Two models of the metabolism of inhaled 241AmO2 in Beagles have been formulated. these models differ in their description of lung retention; the empirical dissolution model uses an empirically derived function to describe dissolution of inhaled 241AmO2 while the surface area model uses a dissolution function based on physical and chemical characteristics of the inhaled aerosol. Both models provide more accurate descriptions of retention data for 241Am from several studies in Beagles than does the model published by the ICRP. The surface area model is extended to describe several cases of inhalation of 241Am in humans. This latter model is employed to calculate Annual Limits of Intake for comparison with results based on the current ICRP model.

Citations

May 1, 1990·American Journal of Respiratory Cell and Molecular Biology·W G KreylingJ D Brain
Jul 1, 1992·Environmental Health Perspectives·W G Kreyling
Feb 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·R A Guilmette, B A Muggenburg
Jan 1, 1989·Critical Reviews in Toxicology·M B Snipes
Mar 7, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Rich Leggett, Eric Blanchardon

Related Concepts

Americium oxide, 241AM-labeled
Aerosol Dose Form
Americium
Canis familiaris
Respiration
Drug or Chemical Tissue Distribution

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