Models of amyotrophic lateral sclerosis

Current Protocols in Neuroscience
Mandy JacksonJeffrey D Rothstein

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.

References

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Citations

Aug 15, 2012·Scientific Reports·Hirotaka TanakaHideaki Hara

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