PMID: 2489052Feb 1, 1989Paper

Models of binding of 4'-nitrophenyl alpha-D-mannopyranoside to the lectin concanavalin A

International Journal of Biological Macromolecules
S J HamodrakasC I Stassinopoulou

Abstract

Molecular models for the complex formed between the lectin concanavalin A (Con A) and the saccharide derivative 4'-nitrophenyl-alpha-D-mannopyranoside (alpha-PNM) are presented, combining evidence from 1H-n.m.r. measurements, semi-empirical energy calculations and interactive graphics modelling. The models are in good agreement with the experimental data. Close examination of the models suggests that hydrophobic interactions together with van der Waals interactions and hydrogen bonds contribute to the stability of the complexes. It appears that there is a limited number of possible modes of binding of alpha-PNM to Con A.

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Citations

Apr 10, 2010·Chemical Communications : Chem Comm·Eugene MahonMihail Barboiu
Jun 12, 1994·Biochimica Et Biophysica Acta·A Troganis, C I Stassinopoulou

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