PMID: 9429160Jan 16, 1998Paper

Models of calcium activation account for differences between skeletal and cardiac force redevelopment kinetics

Journal of Muscle Research and Cell Motility
W O HancockA M Gordon

Abstract

To explain observed differences in the activation dependence of force redevelopment kinetics between cardiac and skeletal muscle, two numerical models of contractile regulation by Ca2+ were investigated. Ca2+ binding and force production were each modelled as two-state processes with forward and reverse rate constants taken from the literature. The first model incorporates four possible thin-filament states. In the second model Ca2+ is assumed not to dissociate from a thin-filament unit in the force-generating state, resulting in three states. The four-state model can account for the activation dependence of the rate constant of tension redevelopment (ktr) seen in skeletal muscle, without requiring that Ca2+ directly modulates the kinetics of any step in the cross-bridge cycle. Using identical kinetic parameters, the three-state model shows no activation dependence of ktr, consistent with our results in cardiac muscle. Following a step increase in [Ca2+], the rate of rise in tension (as described by the rate constant kCa) varies with the final [Ca2+] for both models, consistent with experimental results from skeletal and cardiac muscle. These numerical models demonstrate that experimental measurements thought to reveal changes ...Continue Reading

Citations

Sep 2, 1998·The American Journal of Physiology·A J BakerS A Camacho
Jan 6, 2007·The Journal of Physiology·Alicia Moreno-GonzalezMichael Regnier
Apr 4, 2000·Physiological Reviews·A M GordonM Regnier
Mar 8, 2005·Pflügers Archiv : European journal of physiology·Corrado PoggesiRobert Stehle
Jul 17, 2007·PLoS Computational Biology·Bertrand C W TannerMichael Regnier
Feb 11, 2020·Frontiers in Physiology·Maicon Landim-VieiraJose Renato Pinto
Jul 9, 2013·Cellular and Molecular Bioengineering·Campion K P LoongP Bryant Chase
May 27, 2011·The Journal of Experimental Biology·Todd E Gillis, Jordan M Klaiman
Apr 18, 2021·Biophysical Journal·Wanjian TangChristopher M Yengo
Jun 13, 2006·Archives of Biochemistry and Biophysics·Ye Luo, Jack A Rall
Jan 30, 2004·Biophysical Journal·Hunter MartinRobert J Barsotti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society
A M GordonE Homsher
Journal of Muscle Research and Cell Motility
Masataka Kawai, Herbert R Halvorson
© 2021 Meta ULC. All rights reserved