Models of experimental hypertension in mice

Hypertension
C JohnsH Gavras

Abstract

Experimental models of hypertension in various animals are useful in the research of vasoactive mechanisms. Recombinant DNA technology has produced genetically engineered animals, mostly mice, useful in hypertension research. However, the development of hypertensive models in mice is fraught with technical difficulties. We describe here the successful development in mice of two common types of experimental hypertension: the renovascular two-kidney, one clip and mineralocorticoid deoxycorticosterone-salt models. By adapting technology previously used in rats, we succeeded in developing hypertension (defined as systolic pressures higher than 140 mm Hg) in more than 50% of mice so treated. We also adapted the methodology for indirect tail-cuff blood pressure measurements as well as for direct intra-arterial monitoring of blood pressure in conscious, freely moving mice. Application of these techniques in transgenic or gene knockout mice with altered vasoactive hormones or receptors should allow elucidation of the role of the target gene products in various types of hypertension.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H OhkuboJ Hata
Dec 1, 1994·Kidney International·C E WhitworthJ J Mullins
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·H S KimO Smithies
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·O Smithies, N Maeda
Apr 1, 1994·The American Journal of Physiology·A MoriguchiC M Ferrario
Jan 1, 1993·The American Journal of Physiology·E MillsR Surwit
Mar 7, 1996·The New England Journal of Medicine·A R Shuldiner
Feb 15, 1996·The Journal of Clinical Investigation·K R Chien

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Citations

Apr 11, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Volker VallonFlorian Lang
Feb 27, 2008·Annals of Biomedical Engineering·Yunlong HuoGhassan S Kassab
May 17, 2005·Neurobiology of Aging·Ahmad A ElesberAmir Lerman
Sep 6, 2001·Respiration Physiology·U P Kodavanti, D L Costa
Apr 5, 2003·Toxicology Letters·Daniel L Costa, Urmila P Kodavanti
Aug 31, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ravi Goyal, Lawrence D Longo
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sarah B SunshineMaria Rupnick
May 10, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Robert M BlantonMichael E Mendelsohn
May 20, 2004·Kidney International·Michael ObstFriedrich C Luft
Jul 24, 2008·American Journal of Physiology. Endocrinology and Metabolism·Haruyo YamashitaIra J Goldberg
Mar 18, 2006·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Amanda W WyattFlorian Lang
Mar 15, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Breno V NogueiraElisardo C Vasquez
Jul 11, 2006·The Journal of Clinical Investigation·Dan YangKatya Ravid
Sep 5, 2008·The Journal of Clinical Investigation·Hyung J ChunThomas Quertermous
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Jun 11, 2011·Biomedizinische Technik. Biomedical Engineering·Xuan P NguyenNorbert Gretz
Sep 4, 2014·High Altitude Medicine & Biology·Patricia SiquesFabiola León-Velarde
Nov 11, 2003·Canadian Journal of Physiology and Pharmacology·Sylvie Bobillier-ChaumontAlain Berthelot
Jan 3, 2006·FEBS Letters·Gaetan GavazziKarl-Heinz Krause
Nov 14, 1997·Kidney International·V GrossF C Luft
Sep 4, 2010·European Journal of Medicinal Chemistry·Ozair AlamSadaf J Gilani
Feb 10, 2009·European Journal of Clinical Investigation·K AmannK F Hilgers
Sep 2, 2006·Journal of Neuroscience Methods·Serge C Thal, Nikolaus Plesnila
Aug 13, 2005·Autonomic Neuroscience : Basic & Clinical·Alex A Pérez-RiveraJames J Galligan
Sep 22, 2011·European Journal of Pharmacology·Yoko FujiwaraTaka-aki Koshimizu
Sep 17, 2004·The Journal of Clinical Investigation·Takayuki FujinoFumitaka Ushikubi
Feb 18, 2003·The Journal of Clinical Investigation·Scott P HeximerKendall J Blumer

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