Models of Inflammation: Carrageenan- or Complete Freund's Adjuvant (CFA)-Induced Edema and Hypersensitivity in the Rat

Current Protocols in Pharmacology
Kenneth E McCarson

Abstract

Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the processing of pain sensation at CNS sites, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. Detailed in this unit are methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections into either the footpad or vibrissal pad are described. In this manner, cutaneous inflammation can be assessed in tissue innervated by the lumbar dorsal root ganglion neurons (footpad) or by the trigeminal ganglion neurons (vibrissal pad).

References

Jan 1, 1988·Methods in Enzymology·I G Otterness, P F Moore
Apr 1, 1968·The Journal of Pharmacy and Pharmacology·H Singh, M N Ghosh
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Dec 10, 1999·Neuropharmacology·K E McCarson, S J Enna
Jun 15, 2001·ILAR Journal·Ke Ren, Ronald Dubner
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS
Apr 3, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T M CunhaS H Ferreira
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Rui-Xin ZhangBrian B Berman
May 11, 2005·Scandinavian Journal of Immunology·A MirshafieyM Sotoude
Nov 22, 2007·Experimental Brain Research·Jin-Fei YeoWei-Yi Ong
Mar 14, 2008·The Journal of Pain : Official Journal of the American Pain Society·James R Morgan, G F Gebhart
Apr 25, 2008·Current Protocols in Immunology·John Donovan, Patricia Brown
Feb 22, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·R Denis SoignierHarry J Gould
Mar 10, 2011·Molecular Pain·Ricardo KusudaGuilherme Lucas
Jul 26, 2011·Journal of Neuroscience Methods·Agnieszka KrzyzanowskaCarlos Avendaño
Dec 22, 2012·Current Protocols in Pharmacology·Susan Jones-Bolin
Mar 17, 2015·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E VazquezMercedes López

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Citations

Dec 28, 2016·Muscle & Nerve·Ana BagüésEva M Sánchez-Robles
Jan 9, 2020·Molecular Pain·Bassir CaravanJing Wang
Jun 5, 2020·Psychiatry Investigation·Marjan NikbakhtzadehMohammad Shabani
Apr 17, 2019·Experimental and Therapeutic Medicine·Ahmad A AltarifiMohammad I Alsalem
Nov 20, 2016·Temperature : Multidisciplinary Biomedical Journal·Jennifer R Deuis, Irina Vetter
Feb 13, 2021·Drug Design, Development and Therapy·Zulkifal MalikShupeng Li
Oct 6, 2017·Archives of Oral Biology·Bruna GenariSusana Maria Werner Samuel
Feb 15, 2020·European Journal of Pharmacology·Gilson Gonçalves Dos SantosCarlos Amilcar Parada
Apr 13, 2021·Journal of Food Biochemistry·Zhao TianChi Shang
Jul 11, 2021·Journal of Biomedical Materials Research. Part a·José Carlos Viana RibeiroVilma Lima
May 23, 2020·International Journal of Biological Macromolecules·Paulo Vitor França LemosJanice Izabel Druzian
Apr 9, 2019·International Immunopharmacology·Luiza Carolina França OpretzkaCristiane Flora Villarreal

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