Models of neuronal transient synchrony during propagation of activity through neocortical circuitry

Journal of Neurophysiology
D Golomb

Abstract

Stereotypic paroxysmal discharges that propagate in neocortical tissues after electrical stimulations are used as a probe for studying cortical circuitry. I use modeling to investigate the effects of sparse connectivity, heterogeneity of intrinsic neuronal properties, and synaptic noise on synchronization of evoked propagating neuronal discharges in a network of excitatory, regular spiking neurons with spatially decaying connectivity. The global coherence of the traveling discharge is characterized by the correlation function between spike trains of neurons, averaged over all the pairs of neurons in the system at the same distance. Local coherence of two neurons is characterized by their correlation function averaged over many trials or, for persistent activity, over a long time interval. Spike synchronization between neurons emerges as a result of the transient activity; if activity is persistent, there is no synchrony, and cross-correlation functions are flat. During discharge propagation, system-average cross-correlation between neurons does not depend on their mutual distance except for a time shift. Spike synchronization occurs only when the average number of synapses M a cell receives is large enough. As M increases, ther...Continue Reading

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Citations

Sep 5, 2006·Journal of Computational Neuroscience·D A French, E I Gruenstein
Jan 27, 2009·Journal of Computational Neuroscience·E Alvarez-Lacalle, E Moses
Dec 9, 2000·Neural Computation·H C Tuckwell
Apr 7, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Wim van DrongelenMark Hereld
Oct 12, 2010·Journal of Neurophysiology·Christopher P WarrenGregory A Worrell
Aug 12, 2009·Journal of Biological Physics·Nikolai F Rulkov, Maxim Bazhenov
Feb 22, 2008·Journal of Neurophysiology·Calin I Buia, Paul H Tiesinga
Mar 24, 2016·Scientific Reports·Zahra G EsfahaniAlireza Valizadeh
Jul 19, 2012·The European Journal of Neuroscience·Paul H E Tiesinga
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·D Golomb, G B Ermentrout
Jul 19, 2005·Annual Review of Neuroscience·Tim P VogelsL F Abbott
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Matthew J McGinley, Gary L Westbrook
Aug 22, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David Golomb, G Bard Ermentrout

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