Models of relapse of experimental visceral leishmaniasis

The Journal of Infectious Diseases
H W MurrayR E Fichtl

Abstract

To establish models for studying recurrence of visceral leishmaniasis, a growing problem in T cell-deficient patients, two approaches were investigated: treatment of euthymic BALB/c mice with quiescent Leishmania donovani infection with T cell-depleting or anti-cytokine antibodies and serial observation of acutely infected nude BALB/c mice after an initial antileishmanial response induced by amphotericin B treatment. In chronically infected euthymic mice, maintenance of acquired immunity and prevention of relapse required CD4 cells and a multicytokine-dependent mechanism involving endogenous interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. Acutely infected nude mice responded to amphotericin B with a > or = 85% reduction in liver parasite burdens; however, after a brief lag, visceral infection readily recurred in the posttreatment period. Both models may be useful for testing experimental interventions designed to reduce relapse of previously controlled visceral leishmaniasis in T cell-deficient hosts.

Citations

Jul 14, 2001·Antimicrobial Agents and Chemotherapy·H W Murray
Aug 31, 1996·Lancet·S SundarH W Murray
Feb 17, 2001·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·H W Murray
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Apr 20, 2010·International Journal for Parasitology·Heinrich KörnerPhillip Fromm
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Oct 2, 2001·Cancer Investigation·M GorschlüterT Sauerbruch
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May 7, 2015·Memórias do Instituto Oswaldo Cruz·Sergio Sifontes-RodríguezMiguel Ángel Cabrera-Pérez
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henry W Murray
Nov 13, 2001·International Journal of Experimental Pathology·H W Murray

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