Models of Respiratory Infections: Virus-Induced Asthma Exacerbations and Beyond

Allergy, Asthma & Immunology Research
S SaturniA Papi

Abstract

Respiratory infections are one of the main health problems worldwide. They are a challenging field of study due to an intricate relationship between the pathogenicity of microbes and the host's defenses. To better understand mechanisms of respiratory infections, different models have been developed. A model is the reproduction of a disease in a system that mimics human pathophysiology. For this reason, the best models should closely resemble real-life conditions. Thus, the human model is the best. However, human models of respiratory infections have some disadvantages that limit their role. Therefore, other models, including animal, in vitro, and mathematical ones, have been developed. We will discuss advantages and limitations of available models and focus on models of viral infections as triggers of asthma exacerbations, viral infections being one of the most frequent causes of exacerbating disease. Future studies should focus on the interrelation of various models.

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Citations

Aug 2, 2016·The International Journal of Biochemistry & Cell Biology·Md Mostafizur RahmanAlaina J Ammit
Aug 24, 2016·Journal of Korean Medical Science·Joo Hee KimDong Gyu Kim
Oct 25, 2016·Pharmacology & Therapeutics·Sterghios A MoschosMark A Lindsay
Oct 31, 2018·Respiratory Research·Dennis LoCynthia J Koziol-White
Aug 23, 2020·Journal of Clinical Medicine·Yosuke FukudaHironori Sagara
May 7, 2021·Frontiers in Immunology·Wendy FonsecaCarrie-Anne Malinczak

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Methods Mentioned

BETA
biopsies
transgenic
biopsy

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