Models of stretch-activated ventricular arrhythmias.

Journal of Electrocardiology
Natalia A TrayanovaViatcheslav Gurev

Abstract

One of the most important components of mechanoelectric coupling is stretch-activated channels, sarcolemmal channels that open upon mechanical stimuli. Uncovering the mechanisms by which stretch-activated channels contribute to ventricular arrhythmogenesis under a variety of pathologic conditions is hampered by the lack of experimental methodologies that can record the 3-dimensional electromechanical activity simultaneously at high spatiotemporal resolution. Computer modeling provides such an opportunity. The goal of this review is to illustrate the utility of sophisticated, physiologically realistic, whole heart computer simulations in determining the role of mechanoelectric coupling in ventricular arrhythmogenesis. We first present the various ways by which stretch-activated channels have been modeled and demonstrate how these channels affect cardiac electrophysiologic properties. Next, we use an electrophysiologic model of the rabbit ventricles to understand how so-called commotio cordis, the mechanical impact to the precordial region of the heart, can initiate ventricular tachycardia via the recruitment of stretch-activated channels. Using the same model, we also provide mechanistic insight into the termination of arrhythmi...Continue Reading

References

Oct 1, 1979·Angiology·J L BierfeldB Befeler
Oct 1, 1992·The Journal of Physiology·N HagiwaraH Irisawa
Feb 1, 1990·The Journal of Membrane Biology·C E Morris
Jun 8, 1989·Journal of Theoretical Biology·A T Winfree
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·M A SuleymanianC M Baumgarten
Jun 17, 1994·Annals of the New York Academy of Sciences·D R Van Wagoner, M Lamorgese
May 1, 1993·Circulation Research·D R Van Wagoner
Jun 19, 1998·The New England Journal of Medicine·M S LinkN A Estes
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
Apr 27, 2001·Lancet·A D NesbittP Kohl
May 7, 2003·Progress in Biophysics and Molecular Biology·Tara L Riemer, Leslie Tung
Dec 23, 2004·Journal of Molecular Histology·Weihui LiNatalia Trayanova
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Natalia TrayanovaPeter Kohl
Dec 31, 2005·Physical Review Letters·A V PanfilovM P Nash
Jan 31, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Weihui LiNatalia Trayanova
Nov 30, 2006·Annals of the New York Academy of Sciences·Viatcheslav GurevNatalia A Trayanova
May 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·A V PanfilovM P Nash
Apr 1, 2008·Progress in Biophysics and Molecular Biology·Weihui LiNatalia A Trayanova
Nov 7, 2009·Circulation Research·Xiao JieNatalia Trayanova

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Citations

Jan 8, 2011·Circulation Research·Jason H Yang, Jeffrey J Saucerman
Dec 18, 2013·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·T Alexander Quinn
Oct 3, 2014·Chaos·Jiang-Xing ChenHe-Ping Ying
Nov 19, 2014·Global Cardiology Science & Practice·Alistair ReedRémi Peyronnet
Sep 29, 2011·Journal of Biomedical Optics·Elliot B BourgeoisJack M Rogers
Feb 28, 2013·Journal of Cellular and Molecular Medicine·Ken TakahashiKeiji Naruse
Jan 15, 2014·Journal of Molecular and Cellular Cardiology·Peter Kohl, Robert G Gourdie
Aug 1, 2012·Progress in Biophysics and Molecular Biology·Catherine E MorrisBéla Joós
Jul 25, 2012·Progress in Biophysics and Molecular Biology·Do Yeong KimDavid A Saint
May 22, 2016·Progress in Biophysics and Molecular Biology·T Alexander Quinn, Peter Kohl
Jul 28, 2016·Biophysical Journal·Hanyu ZhangJack M Rogers
Feb 2, 2012·Circulation. Arrhythmia and Electrophysiology·Ross J HunterRichard J Schilling
Feb 4, 2016·Circulation Research·Rémi PeyronnetPeter Kohl
Dec 18, 2013·Journal of Biomechanical Engineering·Emily R PfeifferAndrew D McCulloch
May 1, 2015·Biomedical Engineering Online·Alejandro Lopez-PerezJose M Ferrero
Apr 11, 2015·Journal of Applied Physiology·Andrew FleischmanAndrew R Kohut
Oct 4, 2019·Journal of Cardiovascular Medicine·Assunta CastielloMarco Metra
Oct 9, 2019·Journal of Cardiovascular Medicine·Assunta CastielloMarco Metra
Dec 18, 2019·Experimental Biology and Medicine·Haley W NesmithJack M Rogers
Jun 20, 2020·Heart Failure Reviews·Andrea Lorenzo VecchiMichele Senni
Nov 23, 2020·Indian Pacing and Electrophysiology Journal·Rahul JainJohn M Miller

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