Models of synaptotagmin-1 to trigger Ca2+ -dependent vesicle fusion

FEBS Letters
Yongsoo Park, Je-Kyung Ryu

Abstract

Vesicles in neurons and neuroendocrine cells store neurotransmitters and peptide hormones, which are released by vesicle fusion in response to Ca2+ -evoking stimuli. Synaptotagmin-1 (Syt1), a Ca2+ sensor, mediates ultrafast exocytosis in neurons and neuroendocrine cells. After vesicle docking, Syt1 has two main groups of binding partners: anionic phospholipids and the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) complex. The molecular mechanisms by which Syt1 triggers vesicle fusion remain controversial. This Review introduces and summarizes six molecular models of Syt1: (a) Syt1 triggers SNARE unclamping by displacing complexin, (b) Syt1 clamps SNARE zippering, (c) Syt1 causes membrane curvature, (d) membrane bridging by Syt1, (e) Syt1 is a vesicle-plasma membrane distance regulator, and (f) Syt1 undergoes circular oligomerization. We discuss important conditions to test Syt1 activity in vitro and attempt to illustrate the possible roles of Syt1.

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Citations

Nov 13, 2018·FEBS Letters·Erdem Karatekin, James E Rothman
Jan 31, 2019·Frontiers in Molecular Neuroscience·Grit Bornschein, Hartmut Schmidt
Sep 12, 2020·Biomarker Insights·Elena CamporesiHenrik Zetterberg
Jan 19, 2020·Biophysical Journal·Raya SorkinGijs J L Wuite
Jan 26, 2021·Frontiers in Cell and Developmental Biology·Amra Saric, Spencer A Freeman
Feb 24, 2021·Cellular and Molecular Life Sciences : CMLS·Mónica C Quiñones-Frías, J Troy Littleton
Jun 18, 2021·Archives of Biochemistry and Biophysics·Beyenech BinottiÁngel Pérez-Lara
Nov 10, 2020·Journal of Chemical Theory and Computation·Marcelo CaparottaDiego Masone
Sep 4, 2020·Biophysical Journal·Ramesh Prasad, Huan-Xiang Zhou
Jul 3, 2021·Nature Communications·Murat KirtayZhao-Qi Wang

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