Models of the radiation-induced bystander effect

International Journal of Radiation Biology
Fernando P FariaCarlos H C Moreira

Abstract

To implement quantitative models of the Radiation-Induced Bystander Effects (RIBE) based on cellular excitation at a rate proportional to the concentration of signal molecules (called signals here) released by irradiated cells. Clonogenic cell survival and transformation frequency as a function of rescue time and dose were considered. Our first stochastic model was based on the hypothesis that chemical signals are released into the extracellular medium by irradiated cells. These signals act on unirradiated cells switching them from the healthy to the dead state at rate R(t). We extended this model including a non-lethal transformed state in order to describe clonogenic cell survival and transformation frequency as a function of the number of alpha particles. The first stochastic model was applied to an experiment on human keratinocyte (HaCat) cells yielding the half-life of at least one signal among the ensemble of possible candidates to trigger cell death in this cell culture. The second model yielded good fits to the data on clonogenic cell survival and transformation frequency in microbeam experiments with mouse embryo (C3H10T(1/2)) cells (Sawant et al. 2001a, 2001b). The fit of the first stochastic model to HaCat cell survi...Continue Reading

References

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Citations

Apr 17, 2015·Radiation Protection Dosimetry·P Kundrát, W Friedland
Jul 10, 2014·International Journal of Radiation Biology·Michael J Balderson, Charles Kirkby
Nov 26, 2013·International Journal of Radiation Biology·Michael John Balderson, Charles Kirkby
Oct 1, 2020·Heliyon·Fernando P de FariaSávio L Siqueira

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