PMID: 15244843Jul 13, 2004Paper

Models to analyze small-angle neutron scattering from unilamellar lipid vesicles

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Norbert KucerkaP Balgavý

Abstract

Small-angle scattering has been employed to study the structure of lipid bilayers in unilamellar vesicles. This paper evaluates the use of a model approach for the analysis of such data. A long molecular dynamics simulation of a dipalmitoylphosphatidylcholine bilayer in the L(alpha) phase provides detailed structural information from which scattering length density profiles and scattering intensity are obtained. A sequence of increasingly realistic models are defined and then fit to the simulated scattering intensity data for values of q that are experimentally accessible. The models are evaluated by how well they fit the intensity data and the structural parameters of the simulation. Although the conventional approach that extracts only the radius of gyration from a Kratky-Porod plot provides a reasonable fit to much of the data, the available experimental q range supports refined models with two independent parameters. Of the many two-parameter models, we propose that particular choices should be inspired by the functional form of the scattering length density profile of simulations. Constraints that limit realistic models to two independent parameters are described in detail. The analysis supports the proposition that reliab...Continue Reading

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Citations

Aug 5, 2011·The Journal of Membrane Biology·Jana GallováPavol Balgavý
Oct 28, 2010·European Biophysics Journal : EBJ·Jana GallováPavol Balgavý
Jan 24, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Norbert KucerkaJohn Katsaras
Nov 18, 2005·The European Physical Journal. E, Soft Matter·J PencerJ Katsaras
Apr 14, 2007·The European Physical Journal. E, Soft Matter·A Erbe, R Sigel
Jul 11, 2007·The European Physical Journal. E, Soft Matter·N KucerkaJ Katsaras
Jul 6, 2010·Chemistry and Physics of Lipids·Derek Marsh
Aug 2, 2015·Chemistry and Physics of Lipids·A M Whited, A Johs
Jan 2, 2007·Chemistry and Physics of Lipids·Daniela UhríkováPavol Balgavý
May 30, 2013·Biochimica Et Biophysica Acta·E DrolleZ Leonenko
Jan 21, 2014·Journal of Molecular Graphics & Modelling·Brad Van OostenThad A Harroun
Aug 24, 2010·Chemistry and Physics of Lipids·J GallováP Balgavý
Mar 3, 2009·Biochimica Et Biophysica Acta·Jianjun PanStephanie Tristram-Nagle
Jun 9, 2016·The Journal of Physical Chemistry. B·Liliana G Toscano-FloresMauricio D Carbajal-Tinoco
Aug 2, 2015·Chemistry and Physics of Lipids·Jonathan D NickelsXiaolin Cheng
Feb 18, 2014·Acta Crystallographica. Section D, Biological Crystallography·Selma MaricLise Arleth
Jun 10, 2014·Journal of Chemical Theory and Computation·Michael D DailyNathan A Baker
Apr 7, 2017·Journal of Applied Crystallography·Barbara EicherGeorg Pabst
Apr 15, 2006·European Biophysics Journal : EBJ·M A KiselevR H H Neubert
Apr 11, 2006·The Journal of Membrane Biology·Norbert KucerkaJohn F Nagle
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jianjun PanJohn F Nagle
Jul 16, 2013·The European Physical Journal. E, Soft Matter·Michael MellFrancisco Monroy
May 26, 2017·PLoS Biology·Jonathan D NickelsJohn Katsaras
Jun 2, 2015·Journal of Cardiovascular Development and Disease·Drew MarquardtThad A Harroun
Sep 26, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Y GerelliS Motta
Dec 18, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Mohan Babu Boggara, Ramanan Krishnamoorti
May 15, 2021·Frontiers in Chemistry·Jacob J KinnunJohn Katsaras
Mar 29, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Mu-Ping NiehPeter Macdonald
Dec 11, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Shuo QianLuke A Clifton
Jan 21, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Drew MarquardtGeorg Pabst

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