Moderate alcohol consumption and diseases of the gastrointestinal system: a review of pathophysiological processes

Digestive Diseases
Benjamin Taylor, Jurgen Rehm

Abstract

Alcohol drinking is responsible for a number of gastrointestinal diseases and cancers. Although heavy drinking episodes and chronic drinking are well linked to mechanisms of disease, moderate alcohol consumption and its effects are less well known. This review attempts to fill a gap in the literature surrounding moderate alcohol consumption. A systematic review of the English literature using PubMed was used. A dose-response risk relationship exists between alcohol consumption and digestive disease risk. Acetaldehyde is the main factor in alcohol-related damage in moderate alcohol consumption and acts through numerous methods to exert damaging effects. Zero alcohol intake is recommended for lowest risk of alcohol-related digestive tract diseases and conditions. However, given the lowest overall mortality is associated with moderate drinking, moderate drinking with no bingeing episodes is recommended.

References

Aug 31, 1990·Science·S M Cohen, L B Ellwein
Sep 1, 1983·Scandinavian Journal of Gastroenterology·J A Salo
Aug 1, 1981·Seminars in Liver Disease·R M Jacobs, M F Sorrell
Dec 9, 1997·Journal of the National Cancer Institute·N HomannM Salaspuro
Sep 30, 1998·Recent Developments in Alcoholism : an Official Publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism·H K SeitzU A Simanowski
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R RollaE Albano
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·K ViitalaO Niemelä
Jan 11, 2001·The American Journal of Gastroenterology·L Bujanda
May 15, 2001·Biological Signals and Receptors·C C Cunningham, S M Bailey
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dahn L ClemensDean J Tuma
May 21, 2003·Critical Reviews in Clinical Laboratory Sciences·Mikko P Salaspuro
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Stephan Teyssen, Manfred V Singer
Jun 28, 2003·Best Practice & Research. Clinical Gastroenterology·Mikko P Salaspuro
Jun 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Cristina RigamontiEmanuele Albano
Jan 1, 1961·The Journal of Pathology and Bacteriology·K R REESW G SPECTOR
Dec 20, 2003·Cancer Causes & Control : CCC·Ariana ZekaDavid Kriebel
Feb 24, 2004·American Journal of Epidemiology·Linda Sharp, Julian Little
Aug 2, 2005·Alcohol·Joel B Mason, Sang-Woon Choi
Mar 2, 2006·Digestive Diseases·Benjamin TaylorGerhard Gmel

❮ Previous
Next ❯

Citations

Jul 1, 2009·Journal of Nutrition for the Elderly·Roschelle A Heuberger
May 1, 2008·Journal of Gastroenterology and Hepatology·Sang Woon ParkKi Baik Hahm
Aug 6, 2010·Biological & Pharmaceutical Bulletin·Romina NassiniSerena Materazzi
Apr 5, 2011·Gut and Liver·Yoo Hum BaekOh Young Lee
Dec 22, 2010·Indian Journal of Ophthalmology·Rajul S Parikh, Shefali R Parikh
Feb 14, 2007·Alcoholism, Clinical and Experimental Research·David H AuKatharine A Bradley
Jul 20, 2010·Drug and Alcohol Review·Jürgen RehmMichael Roerecke
Aug 15, 2006·Alcohol·Brenda W C BongaertsMatty P Weijenberg
Feb 23, 2007·The British Journal of Nutrition·Brenda W C BongaertsMatty P Weijenberg
Apr 26, 2006·Expert Opinion on Emerging Drugs·Sylvie BradesiEmeran Mayer
Mar 27, 2021·Biological Trace Element Research·Bertan Boran BayrakRefiye Yanardag

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.