Moderate alcohol consumption and levels of antioxidant vitamins and isoprostanes in postmenopausal women

European Journal of Clinical Nutrition
T J HartmanP R Taylor

Abstract

Although alcohol intake has been positively associated with breast cancer risk in epidemiologic studies, the mechanisms mediating this association are speculative. The Postmenopausal Women's Alcohol Study was designed to explore the effects of moderate alcohol consumption on potential risk factors for breast cancer. In the present analysis, we evaluated the relationship of alcohol consumption with antioxidant nutrients and a biomarker of oxidative stress. Participants (n=53) consumed a controlled diet plus each of three treatments (15 or 30 g alcohol/day or a no-alcohol placebo beverage), during three 8-week periods in random order. We measured the antioxidants, vitamin E (alpha (alpha)- and gamma (gamma)-tocopherols), selenium, and vitamin C in fasting blood samples which were collected at the end of diet periods, treated and frozen for assay at the end of the study. We also measured 15-F(2t)-IsoP isoprostane, produced by lipid peroxidation, which serves as an indicator of oxidative stress and may serve as a biomarker for conditions favorable to carcinogenesis. After adjusting for BMI (all models) and total serum cholesterol (tocopherol and isoprostane models) we observed a significant 4.6% decrease (P=0.02) in alpha-tocophero...Continue Reading

References

Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KawaseC S Lieber
May 1, 1994·Proceedings of the Society for Experimental Biology and Medicine·Y S MaI O LeClair
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B N AmesT M Hagen
Jan 1, 1993·Epidemiologic Reviews·L RosenbergJ R Palmer
Jul 1, 1996·Circulation·M ReillyG A FitzGerald
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·G DaviC Patrono
Feb 28, 1998·JAMA : the Journal of the American Medical Association·S A Smith-WarnerD J Hunter
Aug 13, 1998·The American Journal of Clinical Nutrition·F M Steinberg, A Chait
Dec 22, 1998·Circulation·M P ReillyG A FitzGerald
Jul 9, 1999·Alcoholism, Clinical and Experimental Research·C S Lieber
Sep 24, 1999·The Journal of Clinical Investigation·E A MeagherG A FitzGerald
Nov 26, 1999·Cancer Detection and Prevention·D LiW N Hittelman
Feb 26, 2000·Cardiovascular Research·C PalomboT Sampietro
May 19, 2000·Breast Cancer Research and Treatment·G RayS A Husain
Aug 15, 2000·Annual Review of Nutrition·C S Lieber
Sep 26, 2000·Alcoholism, Clinical and Experimental Research·A ColantoniD H Van Thiel
May 3, 2001·Journal of the National Cancer Institute·J F DorganP R Taylor
Nov 28, 2001·The American Journal of Clinical Nutrition·Q JiangB N Ames
Feb 28, 2002·The American Journal of Clinical Nutrition·David J BaerPhilip R Taylor
Aug 29, 2002·The American Journal of Clinical Nutrition·Han-Yao HuangIan B Puddey
Feb 12, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Alceu Afonso JordãoHelio Vannucchi

❮ Previous
Next ❯

Citations

Apr 8, 2010·Critical Reviews in Food Science and Nutrition·Zorabel CorderoHeiner Boeing
Aug 4, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ilse C SchrieksHenk F J Hendriks
Jun 7, 2008·Human Reproduction Update·Elizabeth H RuderMarlene B Goldman
May 27, 2009·Current Opinion in Obstetrics & Gynecology·Elizabeth H RuderMarlene B Goldman
Nov 20, 2012·Journal of Human Reproductive Sciences·Dilip Gude
Jan 6, 2016·Hormones & Cancer·Terryl J HartmanRegina Ziegler
Mar 24, 2012·Alcohol·Patricia A Masso-WelchStephen T Koury
Dec 7, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Joline W J BeulensHenk F J Hendriks
Nov 6, 2007·Clinical Endocrinology·MaryFran SowersBill Lasley
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Jing ShenRegina M Santella
Feb 7, 2006·Free Radical Biology & Medicine·Manuela Gago-Dominguez, J Esteban Castelao
Jun 27, 2013·Free Radical Research·B SidP B Calderon
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Kenneth J MukamalJohn H Krystal
Feb 28, 2006·The American Journal of Bioethics : AJOB·Denise M Dudzinski
Dec 13, 2019·Cancer Causes & Control : CCC·Joanne F DorganLinda Van Horn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.