PMID: 343739Feb 1, 1978

Moderate and extreme hemodilution in open-heart surgery: fluid balance and acid-base studies

The Annals of Thoracic Surgery
P Lilleaasen, O Stokke


Two groups of patients underwent aortic valve replacement. Fifteen patients received moderate hemodilution (mean hematocrit, 27%) with 40% donor blood in the priming solution. Extreme hemodilution was used in 14 patients (mean hematocrit, 18%) with a nonhemic prime and withdrawal of blood at the start of operation. Both groups were given more than 7 liters of fluid during operation; donor blood was primarily used in the moderately diluted patients, and Ringer's acetate was primarily given to the other group. The diuretic response to this fluid load was much more pronounced in the extreme than in the moderate hemodilution group. Eighteen hours postoperatively, patients in the moderate and extreme hemodilution groups had an excess of about 2 and 1.5 liters of water, respectively. In the patients who had moderate dilution an average of 1,000 ml of erythrocytes disappeared from circulation; no such disappearance could be found in the other group. The moderate group showed significantly lower arterial PO2 postoperatively than the extreme group. There were, however, no differences between the two groups in mixed venous PO2 during perfusion or in acid-base and osmolality values.


Mar 1, 1982·Current Problems in Surgery·R L Thurer, J M Hauer
Oct 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·D HimpeJ Moeskops
Jan 1, 1984·The Annals of Thoracic Surgery·D J Magilligan, C Oyama
May 1, 1981·The Annals of Thoracic Surgery·J R UtleyD B Stephens
Apr 1, 1990·The Annals of Thoracic Surgery·J W JonesD A Lindsley
Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·P LilleaasenT Frøysaker
Jan 1, 1981·Scandinavian Journal of Thoracic and Cardiovascular Surgery·I HørvenO Stokke
Apr 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·P Lilleaasen, O Stokke
May 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·R K ReedO Stokke
Apr 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·P Lilleaasen, O Stokke
Nov 1, 1979·Artificial Organs·J UrzuaJ Dubernet


Jan 25, 1973·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·K MessmerM Kessler
Jun 1, 1973·Annals of Surgery·J L OchsnerN Lawson

Related Concepts

Entire Aortic Valve
Discipline of Heart Surgery
Oxygen Measurement, Partial Pressure, Arterial
Blood Transfusion, Autologous
Cardiac Surgery Procedures
Heart-Lung Machine
Cardiopulmonary Bypass
Specimen Type - Erythrocytes
Osmolality Measurement

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