PMID: 9446843Mar 7, 1998Paper

Moderate and large doses of ethanol differentially affect hepatic protein metabolism in humans

The Journal of Nutrition
E VolpiPierpaolo De Feo

Abstract

The intake of approximately 70 g of alcohol impairs liver protein metabolism in healthy humans. To establish the threshold at which alcohol impairs hepatic protein metabolism in humans we compared the effects of 500 mL of water (control study), 300 (28.4 g ethanol) or 750 mL (71 g ethanol) of table wine on hepatic protein metabolism in three groups of healthy nonalcoholic volunteers. Hepatic protein metabolism was estimated (L-[1-14C]leucine infusion) by measuring the fractional secretory rates of albumin and fibrinogen during the overnight postabsorptive state (basal) and the subsequent administration of water or two different amounts of wine (300 or 750 mL) given with a liquid glucose-lipid-amino acid meal. During the meal, water did not affect fibrinogen fractional secretory rate and increased albumin fractional secretory rate by approximately 50% (P < 0.01). The 300 mL of wine increased albumin secretory rate by only approximately 20% (P < 0.01 vs. basal, P < 0.04 vs. water) and did not affect fibrinogen secretory rate. The 750 mL of wine profoundly impaired hepatic protein metabolism, decreasing the fractional secretory rates of albumin (P < 0.01 vs. water and 300 mL wine) and fibrinogen (P < 0.04 vs. water and 300 mL of w...Continue Reading

References

Feb 1, 1989·Clinical Biochemistry·S W French
Jan 1, 1987·Annals of the New York Academy of Sciences·D J TumaM F Sorrell
Jul 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·C Olsen
Apr 1, 1995·The Journal of Clinical Investigation·P De FeoP Brunetti
Oct 15, 1994·European Journal of Biochemistry·M N BerryA Schön

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Citations

Dec 24, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Paolo Tessari
Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·E VolpiP De Feo
Aug 20, 2015·Nutrients·Caryl Nowson, Stella O'Connell
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C C CunninghamK Torii
Apr 27, 2002·The American Journal of Clinical Nutrition·Paolo TessariElisabetta Iori
Jul 20, 2001·Annals of the New York Academy of Sciences·M P de Maat
Feb 5, 2008·Alcoholism, Clinical and Experimental Research·Napoleon WaszkiewiczKrzysztof Zwierz
Sep 12, 2000·Current Gastroenterology Reports·Y Falck-Ytter, A J McCullough

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