PMID: 6413668Jan 1, 1983Paper

Moderate and severe protein energy malnutrition in childhood: effects on jejunal mucosal morphology and disaccharidase activities

Journal of Pediatric Gastroenterology and Nutrition
H RömerM E Vegas

Abstract

The enzymatic activities of maltase, sucrase, and lactase were determined in jejunal biopsies obtained from 24 children with gastrointestinal symptoms and different degrees of protein energy malnutrition (PEM) to see if these differences were related to the extent of malnutrition or concomitant small intestinal mucosal injury. Even in patients with moderate PEM, lactase activities were significantly lower than control values. The decrease in lactase activity seemed to depend on the severity of malnutrition. In contrast, maltase and sucrase activities were decreased only in second and third degrees of PEM, while no significant changes were observed in first degree and marasmic kwashiorkor. Histologically, all children with PEM had grade I to II mucosal injury which did not correlate with the degree of malnutrition. These results indicate that PEM affects each of the disaccharidases of the jejunal mucosa differently, with lactase being most sensitive to PEM and reflecting most closely the degree of PEM. In contrast, morphological changes showed no correlation with the degree of PEM.

Citations

Mar 6, 1999·Journal of Pediatric Gastroenterology and Nutrition·S K GuptaJ F Fitzgerald
May 19, 2000·Journal of Pediatric Gastroenterology and Nutrition·B L NicholsF R Carrazza
Mar 1, 1997·Archives of Disease in Childhood·D R BrewsterE V O'Loughlin
Aug 26, 2014·PloS One·Maren Johanne Heilskov RytterVibeke Brix Christensen
Nov 1, 1995·JPEN. Journal of Parenteral and Enteral Nutrition·A L BuchmanS R Vijayaroghavan
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Taylor DailedaKalpesh Thakkar
Aug 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Trevor A Winter
Dec 1, 1988·Journal of the American College of Nutrition·S Mobarhan
Jun 1, 1991·Journal of the American College of Nutrition·R Benya, S Mobarhan
Oct 1, 1991·Journal of the American College of Nutrition·W D Jackson, R J Grand

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