Moderate caloric restriction prevents the age-related decline in growth hormone receptor signal transduction

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
X Xu, W E Sonntag

Abstract

A decline in plasma concentration of insulin-like growth factor-1 (IGF-1) has been hypothesized to contribute to a decrease in tissue protein synthesis and function in aging animals and man. In this study, the effects of aging and long-term caloric restriction on growth hormone receptor signal transduction were assessed in hepatic tissue to determine whether alterations in tissue responsiveness to growth hormone contribute to the decline in IGF-1 gene expression. Liver slices from female C57/BL mice (10, 17, and 31 months) were prepared in media and stimulated with growth hormone (2 nM). An increase in growth hormone receptor binding was observed in 31-month ad libitum-fed animals (p < .01) compared to 10- or 17-month-old animals), and this effect was partially attenuated by moderate caloric restriction. However, growth hormone (2 nM)-induced IGF-1 gene expression was significantly lower in old ad libitum-fed animals (p < .05 compared to 10-month-old ad libitum and 31-month-old caloric-restricted animals). Further analysis revealed that growth hormone receptor and JAK2 kinase phosphorylation as well as mitogen-activated protein (MAP) kinase activity were significantly lower in old animals compared to the adult or middle-age gro...Continue Reading

Citations

Oct 27, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J McCarrollG P Moore
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·S X CaoS R Spindler
Jul 19, 2005·Ageing Research Reviews·William E SonntagChristy S Carter
Jun 30, 1998·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·E J Masoro

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