Moderate daily intake of red wine inhibits mural thrombosis and monocyte tissue factor expression in an experimental porcine model

Circulation
L CasaniL Badimon

Abstract

Moderate consumption of red wine has been epidemiologically associated with a reduction in cardiovascular disease, but its mechanism of action is not fully understood. The objective was to study whether the protective effects of a daily intake of red wine (Tempranillo, 12.8% alcohol vol/vol) could be related to inhibition of thrombosis in an experimental model of diet-induced hyperlipemia. For 100 days, animals were fed a western-type proatherogenic diet containing 2% cholesterol and 20% saturated fat. Three doses of red wine were studied (20, 30, and 40 g wine-ethanol/d) and compared with placebo-control animals not taking any wine. Thrombosis under flow conditions was evaluated by radioisotopic quantification of deposited platelets on damaged arteries. Changes in RhoA translocation in platelets and monocyte tissue factor expression were also analyzed. Mural platelet deposition was significantly reduced in animals ingesting red wine with their food. Expression of RhoA in the platelet cytoplasm (inactive form) was increased in wine-fed animals. Tissue factor mRNA expression in lipopolysaccharide-stimulated monocytes was reduced in wine-fed animals. Total cholesterol levels were not significantly different among groups. Moderate...Continue Reading

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Citations

Sep 3, 2013·Vascular Pharmacology·Gemma Vilahur, Lina Badimon
Jul 9, 2005·Journal of Hypertension·Naomi D L Fisher, Norman K Hollenberg
Feb 18, 2012·International Journal of Cardiology·Rajesh Movva, Vincent M Figueredo
May 5, 2007·Annals of Epidemiology·Francois M BooyseEdlue M Tabengwa
May 14, 2016·Nutrition Research Reviews·Eugeni RouraDavid Val-Laillet
Oct 2, 2008·Lupus·A V Kinev, R A S Roubey
Jun 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P PignatelliF Violi
May 8, 2020·Circulation Research·Francesco VioliRoberto Carnevale

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