Moderate-dose methotrexate in head and neck cancer

Oncology
S H AdvaniR Gopal

Abstract

200 mg/m2 methotrexate given intravenously in a running drip for 6 h has been used as an initial adjuvant therapy in 38 patients with advanced head and neck cancer. The response rate is as high as 80%, with 21% achieving complete remission. Histologically, specimens were tumor free in 3 patients. Toxicity in 38 patients included leukopenia (4), mucositis (6) and diarrhea (1). This particular dose of methotrexate appears to be safe and usually does not need leucovorin rescue. Also, when given as initial treatment, it is effective in reduction of tumor bulk. A prolonged randomized trial is essential to determine its role in improving long-term survival.

Citations

May 1, 1991·Journal of Surgical Oncology·R S RaoA R Fakih
Apr 1, 1988·Baillière's Clinical Gastroenterology·K Ewe
Jan 1, 1989·Seminars in Surgical Oncology·S H AdvaniV R Pai
Jan 1, 1985·Seminars in Surgical Oncology·P B DesaiV S Swaroop
Oct 1, 1985·Cancer·S H AdvaniP B Desai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.