Moderate exercise training attenuates inflammatory mediators in DRG of Type 1 diabetic rats

Experimental Neurology
HaeJee YoonMunmun Chattopadhyay

Abstract

Painful neuropathy is a long-term and difficult to treat complication of diabetes that affects 25% of diabetic patients and interferes with their quality of life. Unfortunately, available medical treatments are relatively ineffective due to dependency and addiction. Emerging research indicates that moderate-to-vigorous physical activity provides health-related benefits. However, adequate data is not available to determine whether regular exercise would prevent or delay the development of painful neuropathy in subjects with Type 1 diabetes. This study demonstrates the significance of moderate exercise in the amelioration of pain in animals with Type 1 diabetes after 6weeks of exercise paradigm. After initial acclimatization, streptozotocin-diabetic animals were placed in motorized running wheels for 60minperday, for five days a week for 6weeks starting at one week after diabetes. A growing body of evidence suggests that the release of proinflammatory cytokines plays an important role in the development and persistence of pain. This study demonstrates that moderate exercise increases the expression of inhibitory neurotransmitter enkephalin and also reduces the presence of a number of proinflammatory cytokines in the dorsal root g...Continue Reading

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Citations

Feb 13, 2016·BMC Research Notes·James N SleighGiampietro Schiavo
Mar 29, 2016·Brain Research·Vikram ThakurMunmun Chattopadhyay
Sep 8, 2016·Frontiers in Neuroscience·Michael A CooperDouglas E Wright
Apr 15, 2020·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Grace A Kanzawa-Lee
Mar 19, 2020·Cancer Nursing·Grace A Kanzawa-LeeEllen Marie Lavoie Smith
Jun 25, 2018·Current Osteoporosis Reports·Mark Henry Pitcher
Jan 22, 2020·Seminars in Oncology Nursing·Robert KnoerlEllen M Lavoie Smith
Jan 26, 2021·Pain Reports·Joseph B Lesnak, Kathleen A Sluka

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