Moderate hypothermia as a rescue therapy against intestinal ischemia and reperfusion injury in the rat

Critical Care Medicine
Giorgio StefanuttiSimon Eaton

Abstract

Moderate hypothermia is protective when applied throughout experimental intestinal ischemia and reperfusion (I/R). However, therapeutic intervention is usually possible only after ischemia has occurred. The aim of this study was to evaluate moderate hypothermia when applied at reperfusion as a rescue therapy for intestinal I/R. Prospective, randomized, controlled experiment. University research laboratory. Adult male Sprague-Dawley rats (240-300 g). In experiment I, rats underwent 60 mins of normothermic intestinal ischemia (36-38 degrees C) plus 300 mins of reperfusion at either normothermia or moderate hypothermia (30-32 degrees C) with or without rewarming. Hemodynamics were measured invasively and survival was assessed. In experiment II, rats underwent 60 mins of normothermic ischemia plus 120 mins of reperfusion at either normothermia or moderate hypothermia. At kill, organs and a blood sample were collected. In experiment I, all normothermic I/R rats died within 197 mins of reperfusion after developing severe tachycardia and hypotension, whereas hypothermic rats, with or without rewarming, were alive at 300 mins of reperfusion (p < .001 vs. I/R normothermia) and were hemodynamically stable. In experiment II, normothermic ...Continue Reading

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