Abstract
Experimental data have suggested that hypothermia (32-34 degrees C) may improve outcome after cerebral ischaemia, but its efficacy has not yet been established conclusively in humans. In this study we examined the feasibility and safety of deliberate moderate perioperative hypothermia during operations for subarachnoid aneurysms. A total of 359 operations for intracranial cerebral aneurysms were included in this prospective study. By using cold intravenous infusions (4 degrees C) and convective cooling our aim was to reduce the patient's core temperature to more than 34 degrees C within 1 h before operation. The protocol assessed postoperative complications such as infections, prolonged mechanical ventilation, pulmonary complications and coagulopathies. During surgery, the body temperature was reduced to a mean of 32.5 (SD 0.4) degrees C. Cooling was accomplished at a rate of 4.0 (SD 0.4) degrees C h(-1). All patients were normothermic at 5 (sd 2) h postoperatively. Peri/postoperative complications included circulatory instability (n=36, 10%), arrhythmias (n=17, 5%) coagulation abnormalities and blood transfusion (n=169, 47%), infections (n=29, 8%) and pulmonary complications (infiltrate or oedema while on ventilatory support) ...Continue Reading
References
May 1, 1992·Journal of Neurosurgery·H SävelandG Algers
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·R BustoM D Ginsberg
Nov 1, 1986·The Journal of Hospital Infection·M ShapiroY Kahane
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
Jan 1, 1968·Journal of Neurosurgery·W E Hunt, R M Hess
Jun 1, 1995·Critical Care Medicine·N J SolenskiJ C Torner
Aug 1, 1994·Anesthesiology·K Z BakerR A Solomon
Jan 8, 2000·Stroke; a Journal of Cerebral Circulation·A ZeinerA N Laggner
Feb 24, 2001·The New England Journal of Medicine·G L CliftonM Schwartz
Aug 4, 2001·Stroke; a Journal of Cerebral Circulation·D W KriegerA J Furlan
Dec 12, 2001·Stereotactic and Functional Neurosurgery·C Matula, A Schoeggl
Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Feb 22, 2002·The New England Journal of Medicine·Stephen A BernardKaren Smith
Feb 22, 2002·The New England Journal of Medicine·Peter J Safar, Patrick M Kochanek
Mar 9, 2002·Journal of Neurosurgery·Steen FridrikssonJan Hillman
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·Daniel E CoutureNeal F Kassell
Citations
Sep 4, 2009·Klinische Neuroradiologie·Sandro RossittiJan Hillman
Nov 2, 2017·Neurosurgical Focus·Naif M AlotaibiR Loch Macdonald
Mar 15, 2006·Current Opinion in Anaesthesiology·Akiko Taguchi, Andrea Kurz
Jan 30, 2015·The Cochrane Database of Systematic Reviews·Imelda M GalvinMicheal C Wallace
Oct 5, 2020·Seizure : the Journal of the British Epilepsy Association·Bence CsernyusAnita Pongrácz