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Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats

Critical Care Medicine

Dec 4, 2008

Michael A TortoriciSamuel M Poloyac

Abstract

Therapeutic hypothermia is being clinically used to reduce neurologic deficits after cardiac arrest (CA). Patients receiving hypothermia after CA receive a wide-array of medications. During hypothermia, drug metabolism is markedly reduced. Little, however, is known about the impact of h...read more

Mentioned in this Paper

Neurologic Manifestations
Enzymes, antithrombotic
Cytochrome P450
CYP2E1 gene
Xenobiotic Monooxygenases
Hepatic
Promoter
Cytochrome P450 3A
Rats, Sprague-Dawley
Cytochrome P-450 CYP2E1
Paper Details
References
  • References34
  • Citations12
1234
  • References34
  • Citations12
12

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Mechanisms of CYP450

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Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats

Critical Care Medicine

Dec 4, 2008

Michael A TortoriciSamuel M Poloyac

PMID: 19050605

DOI: 10.1097/ccm.0b013e3181931ed3

Abstract

Therapeutic hypothermia is being clinically used to reduce neurologic deficits after cardiac arrest (CA). Patients receiving hypothermia after CA receive a wide-array of medications. During hypothermia, drug metabolism is markedly reduced. Little, however, is known about the impact of h...read more

Mentioned in this Paper

Neurologic Manifestations
Enzymes, antithrombotic
Cytochrome P450
CYP2E1 gene
Xenobiotic Monooxygenases
Hepatic
Promoter
Cytochrome P450 3A
Rats, Sprague-Dawley
Cytochrome P-450 CYP2E1

Feeds With Similar Papers

Mechanisms of CYP450

Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.

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Paper Details
References
  • References34
  • Citations12
1234
  • References34
  • Citations12
12

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