Moderate intake of red wine improves ischemia-induced neovascularization in diabetic mice--roles of endothelial progenitor cells and nitric oxide

Atherosclerosis
Po-Hsun HuangShing-Jong Lin

Abstract

Circulating endothelial progenitor cells (EPCs) play a significant role in postnatal neovascularization. Patients with diabetes have attenuated EPC functions and impaired angiogenic response after tissue ischemia. We investigated whether moderate red wine consumption can enhance blood flow recovery in response to tissue ischemia by enhancement of EPC functions in diabetic mice. Starting at 4 weeks after diabetes onset, red wine (4 ml/kg/day) or ethanol were administered to streptozotocin (STZ)-induced (type 1) diabetic mice and KKAy-Ta (type 2) mice. Unilateral hind limb ischemia surgery was conducted after 2 weeks of red wine or ethanol ingestion. Type 1 and type 2 diabetic mice given red wine, but not ethanol, had significantly increased collateral flow about 30% and augmented capillary density in ischemic tissues. These beneficial effects were markedly abolished by an eNOS inhibitor (L-NAME). Flow cytometry analysis showed impaired EPC-like cells (Sca-1+/Flk-1+) mobilization after ischemia surgery in diabetic mice, but augmented mobilization in red wine group (baseline vs. 2 days after operation: 0.88±0.06% vs. 1.73±0.29%, p=0.010). C-kit positive bone marrow cells isolated from diabetic mice given red wine had enhanced adhe...Continue Reading

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Citations

Jul 4, 2012·Lipids in Health and Disease·Hui YangSheng-Hua Zhou
Mar 30, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Emiko HoriSatoshi Kuroda
Aug 30, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·San-Yuan WuWen-Chi Chen
Nov 2, 2011·Journal of Molecular and Cellular Cardiology·Maike Krenz, Ronald J Korthuis
May 28, 2016·International Journal of Environmental Research and Public Health·Yue ZhouHua-Bin Li
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Nov 2, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Tao-Cheng WuJaw-Wen Chen
Oct 24, 2018·ACS Biomaterials Science & Engineering·Kristin P O'GradyCraig L Duvall

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