Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes

Therapeutic Advances in Endocrinology and Metabolism
Aleksandra ŻebrowskaBarbara Hall

Abstract

This study aimed to determine the effect of moderate intensity continuous exercise (Ex) and hypoxia (Hyp) on serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), irisin and cytokines levels in patients with type 1 diabetes (T1D). A total of 14 individuals with T1D (age: 28.7 ± 7.3 years) and 14 healthy adults (age: 27.1 ± 3.9 years) performed 40-min continuous Ex at moderate intensity (50% lactate threshold) on a cycle ergometer in normoxia (Nor) and Hyp (FiO2 = 15.1%) Biochemical factors, glucose concentrations and physiological variables were measured at rest, immediately and up to 24 h after both Ex protocols. Patients with T1D had significantly lower pre-Ex serum concentrations of BDNF (p < 0.05, p < 0.01), and total IGF-1 (p < 0.001, p < 0.05) and significantly higher irisin levels (p < 0.05, p < 0.01) in Nor and Hyp, compared with healthy subjects. Ex significantly increased in T1D group serum BDNF (in Nor only p < 0.05) and total IGF-1 levels in Nor and Hyp (p < 0.001 and p < 0.01, respectively). Immediately after Ex in Hyp, freeIGF-1 (p < 0.05) and irisin levels (p < 0.001) were significantly higher compared with the levels induced by Ex alone. Free IG...Continue Reading

References

Jul 18, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R A Collins, M D Grounds
Jan 14, 2005·The New England Journal of Medicine·Irl B Hirsch
Mar 18, 2005·Journal of Applied Physiology·Anne Marie W Petersen, Bente Klarlund Pedersen
Dec 8, 2006·Diabetologia·K S KrabbeB K Pedersen
Feb 23, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·LeAnn M SnowLaDora V Thompson
Apr 3, 2008·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Jaime S RosaPietro R Galassetti
Jul 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laurie J Moyer-MileurMary A Murray
Sep 26, 2008·Clinical Science·Justo Sierra-JohnsonMai-Lis Hellénius
Oct 11, 2008·Medicine and Science in Sports and Exercise·Sven HaufeJens Jordan
Oct 17, 2008·Physiological Reviews·Bente K Pedersen, Mark A Febbraio
Aug 22, 2009·Brain : a Journal of Neurology·C S AndreassenH Andersen
Nov 10, 2010·European Journal of Endocrinology·Harald Jörn SchneiderHenri Wallaschofski
Mar 1, 2011·Brain, Behavior, and Immunity·Bente K Pedersen
Oct 14, 2011·The Journal of Clinical Endocrinology and Metabolism·R MackenzieP Watt
Feb 1, 2012·Diabetes/metabolism Research and Reviews·Henning Andersen
Mar 1, 2012·Journal of Diabetes·Fabian Sanchis-GomarJosé L García-Giménez
Feb 12, 2013·Cell Metabolism·Brendan Egan, Juleen R Zierath
Jun 28, 2013·Aging Cell·Fabio DemontisNorbert Perrimon
Dec 19, 2013·American Journal of Physiology. Endocrinology and Metabolism·Susanne KeipertSusanne Klaus
Jan 31, 2014·Diabetes, Obesity & Metabolism·R A VaughanK A Trujillo
Dec 20, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Cajsa TonoliRomain Meeusen
Jan 2, 2015·Journal of Affective Disorders·Maryna PolyakovaMatthias L Schroeter
Mar 13, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·D EspesP O Carlsson
Jul 28, 2015·International Journal of Sports Medicine·C TonoliR Meeusen
Oct 20, 2015·Progress in Molecular Biology and Translational Science·Sven W GörgensJürgen Eckel
Jan 21, 2016·Archives of Medical Science : AMS·Siresha Bathina, Undurti N Das
Feb 24, 2016·Cell Stress & Chaperones·Xiaofei ChenLingling Zhu
Oct 25, 2016·Medicine and Science in Sports and Exercise·Chip P RowanVeronica K Jamnik
Nov 8, 2016·Journal of Affective Disorders·Roberto CodellaLivio Luzi
Dec 17, 2016·Diabetes Care·UNKNOWN American Diabetes Association

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Citations

Jan 4, 2021·European Journal of Applied Physiology·Pedro B JúdiceLuís B Sardinha
Dec 16, 2020·International Journal of Molecular Sciences·Márton Richárd SzabóCsaba Csonka

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Methods Mentioned

BETA
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Dietus
Statistica versus

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