Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway

Neurochemical Research
Aderbal Silva AguiarRui Daniel Prediger

Abstract

Exercise improves the motor symptoms of patients with Parkinson disease in a palliative manner. Existing evidence demonstrates that exercise induces neuroprotection based on the neurotrophic properties. We investigated the effect of exercise on mitochondrial physiology and oxidative stress in an animal model of hemiparkinsonism. C57BL/6 mice completed a 6-week exercise program on a treadmill. We injected 6-hydroxydopamine (6-OHDA; 4 μg/2 μl) into the midstriatum. The animals progressively developed bradykinesia and R(-)-apomorphine-induced rotations that were attenuated by exercise. Transcriptional activation of protective genes is mediated by the antioxidant response element (ARE). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binds to ARE. We investigated the Nrf2-ARE pathway in the striatum of animals. Exercise protected 6-OHDA-induced loss of tyrosine hydroxylase immunolabeling and activated the Nrf2-ARE pathway in the nigrostriatal pathway. Exercise stimulated mitochondrial biogenesis in the striatum of animals that was more resistant to oxidant 6-OHDA and nitric oxide donor (±)-S-nitroso-N-acetylpenicillamine. In mice, exercise activated Nrf2-ARE signaling in the nigrostriatal pathway that was protective against the ...Continue Reading

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Citations

Oct 16, 2015·Neurotoxicity Research·Aderbal S AguiarRui D Prediger
Oct 23, 2016·Redox Biology·Aaron J Done, Tinna Traustadóttir
Jul 1, 2018·Reviews in the Neurosciences·Jenny Berrío SánchezAlcyr Alves de Oliveira
Sep 20, 2019·Genes·Carlo Maria Di LiegroItalia Di Liegro
Nov 7, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Zeinab RezaeeFahimeh Esfarjani
Aug 18, 2020·Neurotoxicity Research·Zeinab RezaeeFahimeh Esfarjani
Nov 23, 2017·Frontiers in Aging Neuroscience·Lijuan HouFu-Ming Zhou
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Jan 1, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana Elisa Speck, Aderbal S Aguiar
Apr 16, 2019·Frontiers in Neuroscience·Viviane José de Oliveira BristotAderbal Silva Aguiar
Jul 9, 2020·Frontiers in Aging Neuroscience·Grace F Crotty, Michael A Schwarzschild
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