Moderate kidney disease inhibits atherosclerosis regression.

Atherosclerosis
Manish P PondaEdward Y Skolnik

Abstract

Chronic kidney disease (CKD) accelerates cardiovascular disease. The mechanisms that explain this independent, excess risk associated with CKD have not been fully elucidated. We propose that impaired regression of atherosclerosis in renal disease represents a novel risk factor for the heightened morbidity and mortality and resistance to treatment observed in patients with CKD. Using a transplant model to study atherosclerosis regression, we transplanted atheromatous aortic segments generated in Apolipoprotein E knock-out (ApoE(-/-)) mice, into either control or moderately uremic, normolipidemic, wild-type mice. In non-uremic mice, lesions regressed 55%, whereas lesions in uremic mice increased in size by 17% (p<0.01 for control vs. uremic). The lesions in uremic mice were also characterized by a greater presence of macrophages (36,300 microm(2) vs. 12,600 microm(2), p<0.01). This finding was despite upregulation of chemokine receptor 7 (CCR7), normally a migration factor, in uremic lesion macrophages. Gene expression analysis of lesion macrophages showed relative down-regulation of serum response factor (SRF) target genes in the uremic group, consistent with impaired CCR7 signaling. Moderate kidney disease inhibits regression o...Continue Reading

References

Jan 23, 2003·Journal of the American Society of Nephrology : JASN·Moriz BuzelloKerstin Amann
Jul 10, 2003·The Journal of Surgical Research·Igor ChereshnevErnane D Reis
Sep 30, 2003·Journal of the American Society of Nephrology : JASN·Susanne BroLars B Nielsen
Jan 21, 2004·Blood Purification·Vincenzo D'IntiniClaudio Ronco
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jaime LlodráGwendalyn J Randolph
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jul 22, 2005·The New England Journal of Medicine·Christoph WannerUNKNOWN German Diabetes and Dialysis Study Investigators
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eugene TroganEdward A Fisher
Oct 13, 2006·Trends in Cell Biology·Guido Posern, Richard Treisman
Sep 11, 2007·Nature Medicine·Zeneng WangStanley L Hazen
Nov 1, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Srinivasan BeddhuUNKNOWN Hemodialysis (HEMO) Study Group
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Jan 29, 2008·Nature Clinical Practice. Cardiovascular Medicine·Kevin Jon WilliamsEdward A Fisher
Feb 16, 2008·Kidney International·K SusztakT H Hostetter
Sep 4, 2008·Seminars in Dialysis·Manish P Ponda, Irina Barash
Apr 1, 2009·The New England Journal of Medicine·Bengt C FellströmUNKNOWN AURORA Study Group

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Citations

Nov 26, 2010·Nature Reviews. Nephrology·Valentina KonSergio Fazio
Apr 23, 2013·Immunity·Kathryn J Moore, Edward A Fisher
Aug 16, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·José M ValdivielsoAlberto Ortiz
Jun 21, 2015·Journal of Cell Science·Katrin HolstEvgeni Ponimaskin

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