Moderate mutation rate in the SARS coronavirus genome and its implications

BMC Evolutionary Biology
Zhongming ZhaoYun-Xin Fu

Abstract

The outbreak of severe acute respiratory syndrome (SARS) caused a severe global epidemic in 2003 which led to hundreds of deaths and many thousands of hospitalizations. The virus causing SARS was identified as a novel coronavirus (SARS-CoV) and multiple genomic sequences have been revealed since mid-April, 2003. After a quiet summer and fall in 2003, the newly emerged SARS cases in Asia, particularly the latest cases in China, are reinforcing a wide-spread belief that the SARS epidemic would strike back. With the understanding that SARS-CoV might be with humans for years to come, knowledge of the evolutionary mechanism of the SARS-CoV, including its mutation rate and emergence time, is fundamental to battle this deadly pathogen. To date, the speed at which the deadly virus evolved in nature and the elapsed time before it was transmitted to humans remains poorly understood. Sixteen complete genomic sequences with available clinical histories during the SARS outbreak were analyzed. After careful examination of multiple-sequence alignment, 114 single nucleotide variations were identified. To minimize the effects of sequencing errors and additional mutations during the cell culture, three strategies were applied to estimate the mut...Continue Reading

References

Jul 1, 1969·Scientific American·M O Dayhoff
Aug 1, 1997·Molecular Biology and Evolution·Y Suzuki, T Gojobori
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M BushW M Fitch
Feb 22, 2001·Science·J C VenterX Zhu
Dec 26, 2001·Bioinformatics·S KumarM Nei
Mar 28, 2003·Nature·Neil M FergusonRobin M Bush
Apr 3, 2003·The New England Journal of Medicine·Susan M PoutanenUNKNOWN Canadian Severe Acute Respiratory Syndrome Study Team
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
May 6, 2003·Science·Marco A MarraRachel L Roper
Dec 19, 2003·The New England Journal of Medicine·Fanya ZengFrederick C Leung
Jan 9, 2004·Nature·David Cyranoski
Jan 31, 2004·Science·UNKNOWN Chinese SARS Molecular Epidemiology Consortium

❮ Previous
Next ❯

Citations

Jan 4, 2005·BMC Genomics·Marit S Bratlie, Finn Drabløs
May 23, 2013·Emerging Infectious Diseases·Matthew CottenEleni Nastouli
Nov 27, 2015·Molecular Biology and Evolution·Arlin Stoltzfus, Ryan W Norris
Apr 25, 2007·Virus Research·Zhengli Shi, Zhihong Hu
Aug 26, 2017·The Journal of General Virology·Sonu SubudhiVikram Misra
Feb 7, 2020·Journal of Medical Virology·Xingguang LiAntoine Chaillon
Jan 31, 2020·Journal of Medical Virology·Xingguang LiYi Li
Feb 28, 2020·Journal of Medical Virology·Xingguang LiAntoine Chaillon
Jul 8, 2020·Pathogens·Ahmed S Abdel-Moneim, Elsayed M Abdelwhab
Aug 8, 2020·International Journal of Molecular Sciences·Mathieu GandSigrid C J De Keersmaecker
Feb 9, 2018·PLoS Pathogens·Finlay CampbellThibaut Jombart
Mar 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zijie ShenMingkun Li
Jul 2, 2020·International Journal of Molecular Sciences·Alejandro LlanesRicardo Lleonart
Jul 25, 2020·Science·Darlan S CandidoNuno Rodrigues Faria
Aug 4, 2020·Bulletin of the World Health Organization·Takahiko KoyamaLaxmi Parida
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Mar 30, 2019·PLoS Computational Biology·Finlay CampbellThibaut Jombart
Apr 20, 2020·Transboundary and Emerging Diseases·Denis C BauerSeshadri S Vasan
Sep 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Bethany DearloveMorgane Rolland
May 11, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Franz RödelUdo S Gaipl
Aug 4, 2020·Royal Society Open Science·Kashif Aziz Khan, Peter Cheung
Aug 25, 2020·Inflammation and Regeneration·So Nakagawa, Takayuki Miyazawa
Sep 6, 2020·Molecular Genetics and Genomics : MGG·Yue LiWenqing Jiang
Sep 24, 2020·Journal of Medical Virology·Matías J PeresonFederico A Di Lello
Nov 27, 2020·Nature Communications·Lucy van DorpFrançois Balloux
Dec 23, 2020·PloS One·Yulong WeiXuhua Xia
Jan 5, 2021·Human Vaccines & Immunotherapeutics·Firzan NainuHarapan Harapan
Dec 29, 2020·International Journal of Biological Macromolecules·Martina BianchiStefano Pascarella
Jan 22, 2021·Xenotransplantation·Tanja Opriessnig, Yao-Wei Huang
Jan 27, 2021·JMIR Bioinformatics and Biotechnology·Emilio MastrianiShu-Lin Liu
Aug 4, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Navpreet KaurTanzeer Kaur
Feb 11, 2021·Life·Maria VasilarouPavlos Pavlidis

❮ Previous
Next ❯

Software Mentioned

CLUSTAL X
MEGA2
CLUSTAL W

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.