Moderate neonatal hypoglycemia and adverse neurological development at 2-6 years of age

European Journal of Epidemiology
Ronny WickströmMaria Altman

Abstract

To determine whether moderate neonatal hypoglycemia in otherwise healthy infants is associated with adverse neurodevelopmental outcome in pre-school children. Population-based cohort study with prospectively collected register data from Sweden. All singletons born July 1st 2008 through December 31st 2012 (n = 101,060) in the region were included. Infants with congenital malformations, infants treated in neonatal intensive care unit, infants with inborn errors of metabolism and infants to mothers with diabetes were excluded. Infants were followed-up until 2014, at 2-6 years of age. Exposure was neonatal moderate hypoglycemia. Main outcomes were a compiled neurological or neurodevelopmental outcome; any developmental delay; motor developmental delay; and cognitive developmental delay. In adjusted regression analyses, the odds ratio (OR) of any neurological or neurodevelopmental outcome was 1.48 (95% confidence interval: 1.17-1.88) in hypoglycemic compared to normoglycemic infants. The adjusted risk of any developmental delay was more than doubled (OR 2.53 [1.71-3.73]), the adjusted risk of motor developmental delay was almost doubled (OR: 1.91 [1.06-3.44]) and the adjusted risk of cognitive developmental delay was almost tripled ...Continue Reading

References

Nov 19, 1988·BMJ : British Medical Journal·A LucasT J Cole
Aug 1, 1967·Journal of Neurology, Neurosurgery, and Psychiatry·J M AndersonS J Strich
Feb 1, 2002·International Journal of Epidemiology·A J Wilcox
Jun 9, 2009·European Journal of Epidemiology·Jonas F LudvigssonAnders Ekbom
Jul 11, 2012·Pediatrics·Jorien M KerstjensArend F Bos
Oct 23, 2012·Archives of Disease in Childhood. Education and Practice Edition·James P BoardmanFrances M Cowan
Nov 7, 2012·Pediatrics·Win TinSusan Fritz
Oct 24, 2013·Seminars in Fetal & Neonatal Medicine·Win Tin
May 27, 2015·European Journal of Epidemiology·Maria AltmanOlof Stephansson
Aug 25, 2015·JAMA Pediatrics·Christopher J D McKinlay, Jane E Harding
Oct 16, 2015·The New England Journal of Medicine·Christopher J D McKinlayUNKNOWN CHYLD Study Group
Aug 8, 2017·JAMA Pediatrics·Christopher J D McKinlayUNKNOWN Children With Hypoglycemia and Their Later Development (CHYLD) Study Team

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Citations

May 6, 2020·European Journal of Epidemiology·M Arfan IkramTrudy Voortman
Sep 24, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Marina S OrenTara L DuPont
Apr 9, 2020·The Cochrane Database of Systematic Reviews·Kwi MoonShripada C Rao
Sep 15, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Melania RivanoCinzia Veneziano
Jan 9, 2021·Seizure : the Journal of the British Epilepsy Association·Francesco PisaniGeorgia Ramantani
Apr 10, 2021·The Lancet Child & Adolescent Health·Jane M AlsweilerChristopher J D McKinlay
May 21, 2021·Hospital Pediatrics·Sudha Rani NarasimhanPriya Jegatheesan
May 24, 2020·Seizure : the Journal of the British Epilepsy Association·Dipti KapoorHarish K Pemde
Aug 5, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mesk AlraisMichal Fishel Bartal
Aug 18, 2021·Obesity Science & Practice·Marissa S RodensteinJami L Josefson

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Methods Mentioned

BETA
Cesarean
SGA

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