Moderate or supranormal folic acid supplementation does not exert a protective effect for homocysteinemia and methylation markers in growing rats

Annals of Nutrition & Metabolism
Teresa PartearroyoGregorio Varela-Moreiras

Abstract

Folic acid (FA) deficiency/supplementation effects seem to be dependent on age group and/or physiological status. The aim was to evaluate changes associated with rapid growth in relation to methionine metabolism in rats. Four groups (n = 10 each) of male Sprague Dawley rats (5 weeks old) were on diets that varied in their FA content: 0 mg FA/kg diet (deficient), 2 mg FA/kg diet (control), 8 mg FA/kg diet (moderate supplementation), 40 mg FA/kg diet (supranormal supplementation). Animals were fed ad libitum for 30 days. Biomarkers of methionine metabolism and antioxidant status were evaluated. Serum total homocysteine concentration increased (p < 0.01) in FA deficient animals, with no differences between the supplemented groups. The hepatic 'methylation ratio' (S-adenosylmethionine/S-adenosylhomocysteine) of the FA content groups reached similar values, which were significantly higher compared to the deficient group. The brain 'methylation ratio', however, remained unmodified independently of FA content in the diet. FA deficiency induced hepatic DNA hypomethylation, and supranormal FA supplementation exerted the most protective effect (p < 0.01). Serum folate levels increased according to FA dietary level, whereas no differences...Continue Reading

Citations

Jul 27, 2012·European Journal of Nutrition·Teresa PartearroyoGregorio Varela-Moreiras
Sep 26, 2015·Journal of Physiology and Biochemistry·Yusof KamisahAhmad Yusof Asmadi
Oct 1, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Carmen Maestro-de-las-CasasConcepción Martínez-Álvarez
Nov 22, 2013·Nutritional Neuroscience·Pratiksha SableSadhana Joshi
May 8, 2016·The British Journal of Nutrition·Teresa PartearroyoGregorio Varela-Moreiras
Mar 31, 2011·Mutation Research·Cátia Lira Do AmaralLusânia Maria Greggi Antunes
Feb 13, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Natalia ÚbedaGregorio Varela-Moreiras
Dec 17, 2016·Journal of Cellular Biochemistry·Avisek MajumderSuresh C Tyagi

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