Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Ryan J DoughertyOzioma C Okonkwo

Abstract

The objective of this study was to investigate the relationship between accelerometer-measured physical activity (PA) and glucose metabolism in asymptomatic late-middle-aged adults. Ninety-three cognitively healthy late-middle-aged adults from the Wisconsin Registry for Alzheimer's Prevention participated in this cross-sectional study. They underwent 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and wore an accelerometer (ActiGraph GT3X+) to measure free-living PA. Accelerometer data yielded measures of light (LPA), moderate (MPA), and vigorous (VPA) intensity PA. FDG-PET images were scaled to the cerebellum and pons, and cerebral glucose metabolic rate was extracted from specific regions of interest (ROIs) known to be hypometabolic in AD, i.e., hippocampus, posterior cingulate, inferior temporal cortex, and angular gyrus. Regression analyses were utilized to examine the association between PA and glucose metabolism, while adjusting for potential confounds. There were associations between MPA and glucose metabolism in all ROIs examined. In contrast, LPA was not associated with glucose uptake in any ROI and VPA was only associated with hippocampal FDG uptake. Secondary analyses did not reveal associations...Continue Reading

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Citations

Mar 2, 2018·Current Treatment Options in Neurology·Po-Heng Tsai
Jan 13, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Sterling C JohnsonMark A Sager
Mar 13, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Lena L LawOzioma C Okonkwo
Jun 27, 2020·JAD Reports·Julian M GaitánOzioma C Okonkwo
Feb 28, 2020·Behavioural Neurology·Hallie NuzumStacy Schantz Wilkins
Aug 25, 2021·Neurobiology of Aging·Victoria FlemingSigan L Hartley
Oct 13, 2021·Human Brain Mapping·Eric GuedjMathieu Ceccaldi
Sep 29, 2021·The British Journal of Nutrition·Étienne Myette-CôtéStephen C Cunnane

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