Moderate running exercise prevents excessive immune system activation

Physiology & Behavior
Débora da Luz SchefferAlexandra Latini

Abstract

Benefits of exercise have been documented for many diseases with a chronic progression, including obesity, diabetes mellitus, cardiovascular diseases, neurodegenerative diseases, certain types of cancers, and overall mortality. Low-grade systemic inflammation is a key component of these pathologies and it has been demonstrated that can be prevented by performing regularly physical exercise. The aim of this study was to examine the effect of lipopolysaccharide (LPS)-induced inflammation on glucose and insulin tolerance, exercise performance, production of urinary neopterin and striatal neurotransmitters levels in adult male C57BL/6 mice. Increased blood glucose clearance and insulin sensitivity were observed after a single administration of glucose (2 g/kg, p.o.) or insulin (0.5 U/kg, i.p.). However, the repeated injection of LPS (0.33 mg/kg/day, i.p.) decreased glucose tolerance and increase urinary neopterin levels, pointing to systemic inflammation. In parallel to the urinary-increased neopterin, it was observed a significant reduction in the striatal dopamine levels and an increase in the serotonin/dopamine ratio. While a single LPS injection (0.33 mg/kg, i.p.) showed impaired performance in the incremental loading test (10 ...Continue Reading

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Citations

May 4, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Débora da Luz Scheffer, Alexandra Latini
Mar 21, 2021·Biological Trace Element Research·Ibrahim UgurluAbdulkerim Kasim Baltaci
Apr 10, 2021·Frontiers in Neuroscience·Gisele EspíndolaAlexandra Latini
Aug 18, 2021·Neuroscience and Biobehavioral Reviews·Douglas Buchmann GodinhoLuiz Fernando Freire Royes
Aug 24, 2021·Brain Communications·Débora da Luz SchefferAlexandra Latini

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