Moderate-to-vigorous physical activity and leisure-time sitting in relation to ovarian cancer risk in a large prospective US cohort

Cancer Causes & Control : CCC
Janet S HildebrandAlpa V Patel

Abstract

Physical activity is hypothesized to lower the risk of ovarian cancer, but current evidence for an association is limited and inconclusive. The purpose of this study was to examine moderate-to-vigorous physical activity, walking, and leisure-time sitting in relation to incident ovarian cancer, overall and by histologic subtype. Moderate-vigorous recreational physical activity (MET-hours/week), recreational walking, and leisure-time sitting were examined in relation to epithelial ovarian cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort, a US cohort followed for cancer incidence from 1992 to 2011. Exposure information was collected via self-administered questionnaires. Cox proportional hazards regression was used to estimate multivariable-adjusted relative risks (RRs) and 95% confidence intervals (CIs) of total, serous, and nonserous ovarian cancer according to MET-hours/week, hours/week of walking, and hours/day of sitting. Among 63,972 postmenopausal women, 651 cases of ovarian cancer were identified during follow-up. Neither MET-hours/week nor walking was associated with risk. However, ≥6 h/day of sitting, compared to <3, was associated with higher risk of ovarian cancer (RR 1.44, 95% CI 1.12-1...Continue Reading

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Citations

Oct 17, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Penelope M Webb, Susan J Jordan
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Jul 18, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Orit Gressel RazEran Ben-Arye
Jun 15, 2019·International Journal of Cancer. Journal International Du Cancer·Anne GrundyAnita Koushik
May 20, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Rikki CanniotoKirsten B Moysich
Jan 26, 2021·European Journal of Epidemiology·Veronika S BillerCarmen Jochem
Mar 12, 2021·Cancer Medicine·Andrea L BurasShelley S Tworoger

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