Moderate use of alcohol is associated with lower levels of C reactive protein but not with less severe joint inflammation: a cross-sectional study in early RA and healthy volunteers

RMD Open
Lukas MangnusAnnette H M van der Helm-van Mil

Abstract

Moderate alcohol consumption is protective against rheumatoid arthritis (RA) development and associated with lower levels of systemic inflammation in RA and in the general population. We therefore hypothesised that moderate alcohol consumption is associated with less severe local inflammation in joints in RA, detected by MRI. Since asymptomatic persons can have low-grade MRI-detected inflammation, we also hypothesised that alcohol consumption is associated with the extent of MRI inflammation in asymptomatic volunteers. 188 newly presenting patients with RA and 192 asymptomatic volunteers underwent a unilateral contrast-enhanced 1.5T MRI of metacarpophalangeal, wrist and metatarsophalangeal joints. The MRIs were scored on synovitis, bone marrow oedema and tenosynovitis; the sum of these yielded the MRI inflammation score. MRI data were evaluated in relation to current alcohol consumption, categorised as non-drinkers, consuming 1-7 drinks/week, 8-14 drinks/week and >14 drinks/week. Association between C reactive protein (CRP) level and alcohol was studied in 1070 newly presenting patients with RA. Alcohol consumption was not associated with the severity of MRI-detected inflammation in hand and foot joints of patients with RA (P=0...Continue Reading

Citations

Jan 5, 2020·Stress : the International Journal on the Biology of Stress·João Pedro Costa-NunesCareen A Schroeter
Oct 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raja Mohamed Beema ShafreenShela Gorinstein
Mar 22, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Brian R CarrBrian P Ford
Jun 8, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Marie Charlotte DesmottesAthan Baillet
Jul 6, 2021·Gut Microbes·Blaine CaslinEsther Melamed

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