Moderate weight loss in obese and overweight men preserves bone quality

The American Journal of Clinical Nutrition
L Claudia PopS A Shapses

Abstract

Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women. In this prospective controlled trial, we examined variables of bone quality and endocrine changes after intentional WL in men. Thirty-eight overweight and obese [mean ± SD body mass index (in kg/m²): 31.9 ± 4.4; age: 58 ± 6 y] men were recruited to either WL through caloric restriction or weight maintenance (WM) for 6 mo. There was a -7.9 ± 4.4% and +0.2 ± 1.6% change in body weight in the WL and WM groups, respectively. There was a greater increase in femoral neck and total body BMD and bone mineral content (BMC) in the WM group than in the WL group (P-interaction effect < 0.05). In contrast, there was a trend for the tibia cortical thickness and area to decrease more in the WM group than in the WL group (P ≤ 0.08). There was a decrease in the periosteal circumference in both groups over time (P < 0.01) and no statistically significant changes in trabecular bone. Circulating total, free, and bioavailable estradiol decreased in the WL group compared with the WM group, and changes were different between groups (P < 0.05). Serum total and bioavailable testosterone increased in both groups (P < 0.01). Serum...Continue Reading

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Nov 26, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anne L Schafer
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