Moderator's view: Predictive models: a prelude to precision nephrology

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Carmine Zoccali

Abstract

Appropriate diagnosis is fundamental in medicine because it sets the basis for the prediction of disease outcome at the single patient level (prognosis) and decisions regarding the most appropriate therapy. However, given the large series of social, clinical and biological factors that determine the likelihood of an individual's future outcome, prognosis only partly depends on diagnosis and aetiology and treatment is not decided solely on the basis of the underlying diagnosis. This issue is crucial in multifactorial diseases like atherosclerosis, where the use of statins has now shifted from 'treating hypercholesterolaemia' to 'treating the risk of adverse cardiovascular events'. Approaches that take due account of prognosis limit the lingering risk of over-diagnosis and maximize the value of prognostic information in the clinical decision process. In the nephrology realm, the application of a well-validated risk equation for kidney failure in Canada led to a 35% reduction in new referrals. Prognostic models based on simple clinical data extractable from clinical files have recently been developed to predict all-cause and cardiovascular mortality in end-stage kidney disease patients. However, research on predictive models in re...Continue Reading

References

May 29, 1987·The American Journal of Cardiology·P W WilsonW B Kannel
Apr 13, 2011·JAMA : the Journal of the American Medical Association·Navdeep TangriAndrew S Levey
Nov 19, 2013·Journal of the American College of Cardiology·Neil J StoneUNKNOWN American College of Cardiology/American Heart Association Task Force on Practice Guidelines
Apr 4, 2014·Kidney International·Rosanna CoppoUNKNOWN VALIGA study of the ERA-EDTA Immunonephrology Working Group
Jan 13, 2016·JAMA : the Journal of the American Medical Association·Navdeep TangriUNKNOWN CKD Prognosis Consortium
May 4, 2016·International Journal of Cardiology·Stefan D AnkerUNKNOWN On behalf the ARO Steering Committee (collaborators)

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Citations

Nov 17, 2019·Journal of the American Society of Nephrology : JASN·Liang LiTom Greene
Aug 12, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Charmaine E LokUNKNOWN National Kidney Foundation

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