Modern developments in mass spectrometry of chondroitin and dermatan sulfate glycosaminoglycans

Amino Acids
Eugen SisuAlina Zamfir

Abstract

Chondroitin sulfate (CS) and dermatan sulfate (DS) are special types of glycosaminoglycan (GAG) oligosaccharides able to regulate vital biological functions that depend on precise motifs of their constituent hexose sequences and the extent and location of their sulfation. As a result, the need for better understanding of CS/DS biological role called for the elaboration and application of straightforward strategies for their composition and structure elucidation. Due to its high sensitivity, reproducibility, and the possibility to rapidly generate data on fine CS/DS structure determinants, mass spectrometry (MS) based on either electrospray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI) brought a major progress in the field. Here, modern developments in MS of CS/DS GAGs are gathered in a critical review covering the past 5 years. The first section is dedicated to protocols for CS/DS extraction from parent proteoglycan, digestion, and purification that are among critical prerequisites of a successful MS experiment. The second part highlights several MALDI MS aspects, the requirements, and applications of this ionization method to CS/DS investigation. An ample chapter is devoted to ESI MS strategies, which...Continue Reading

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Citations

May 20, 2011·Amino Acids·Hartmut Schlüter, Peter R Jungblut
Apr 20, 2012·Molecular BioSystems·Lingyun LiRobert J Linhardt
Oct 16, 2013·Antioxidants & Redox Signaling·Beate Fuchs, Jürgen Schiller
Feb 19, 2013·Expert Review of Proteomics·Bernd GesslbauerAndreas J Kungl
Mar 1, 2012·Journal of Magnetic Resonance·Derek J LangeslayCynthia K Larive
Jun 15, 2014·Biochemical and Biophysical Research Communications·Nadezda KiselovaMargareta Ramström
Dec 8, 2016·Glycoconjugate Journal·Baptiste SchindlerIsabelle Compagnon
Jul 7, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yuefan SongRobert J Linhardt
Oct 6, 2021·Mass Spectrometry Reviews·Andreas ZappeKevin Pagel

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